Coccidioides posadasii produces melanin in vitro and during infection

Joshua D. Nosanchuk, Jieh Juen Yu, Chiung Yu Hung, Arturo Casadevall, Garry T. Cole

Research output: Contribution to journalArticle

Abstract

Using techniques developed to study melanization in other fungi, we demonstrate that Coccidioides posadasii arthroconidia, spherules, and endospores produce melanin or melanin-like compounds in vitro and tissue forms synthesize pigment in vivo. Since melanin is an important virulence factor in other pathogenic fungi, it may affect the pathogenesis of coccidioidomycosis.

Original languageEnglish (US)
Pages (from-to)517-520
Number of pages4
JournalFungal Genetics and Biology
Volume44
Issue number6
DOIs
Publication statusPublished - Jun 2007
Externally publishedYes

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Keywords

  • Coccidioides
  • Fungi
  • Melanin
  • Virulence factor

ASJC Scopus subject areas

  • Genetics
  • Microbiology

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