Coccidioides posadasii produces melanin in vitro and during infection

Joshua D. Nosanchuk, Jieh Juen Yu, Chiung Yu Hung, Arturo Casadevall, Garry T. Cole

Research output: Contribution to journalArticle

Abstract

Using techniques developed to study melanization in other fungi, we demonstrate that Coccidioides posadasii arthroconidia, spherules, and endospores produce melanin or melanin-like compounds in vitro and tissue forms synthesize pigment in vivo. Since melanin is an important virulence factor in other pathogenic fungi, it may affect the pathogenesis of coccidioidomycosis.

Original languageEnglish (US)
Pages (from-to)517-520
Number of pages4
JournalFungal Genetics and Biology
Volume44
Issue number6
DOIs
StatePublished - Jun 2007
Externally publishedYes

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Coccidioides
Melanins
Fungi
Infection
Coccidioidomycosis
Virulence Factors
In Vitro Techniques

Keywords

  • Coccidioides
  • Fungi
  • Melanin
  • Virulence factor

ASJC Scopus subject areas

  • Genetics
  • Microbiology

Cite this

Coccidioides posadasii produces melanin in vitro and during infection. / Nosanchuk, Joshua D.; Yu, Jieh Juen; Hung, Chiung Yu; Casadevall, Arturo; Cole, Garry T.

In: Fungal Genetics and Biology, Vol. 44, No. 6, 06.2007, p. 517-520.

Research output: Contribution to journalArticle

Nosanchuk, Joshua D. ; Yu, Jieh Juen ; Hung, Chiung Yu ; Casadevall, Arturo ; Cole, Garry T. / Coccidioides posadasii produces melanin in vitro and during infection. In: Fungal Genetics and Biology. 2007 ; Vol. 44, No. 6. pp. 517-520.
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