Cocaine's effects on the discrimination of simple and complex auditory stimuli by baboons

Robert D Hienz, Michael R. Weed, Troy J. Zarcone, Joseph V. Brady

Research output: Contribution to journalArticle

Abstract

The effects of cocaine on tone frequency discriminations by baboons were examined and compared with previous data for more complex acoustic stimuli (speech sounds) to see if cocaine's perceptual effects on these discriminations depends upon the type of stimulus employed (i.e., tones vs. speech sounds). Baboons pressed a lever to produce one repeating "standard" tone and released the lever only when one of four other "comparison" tones occasionally occurred in place of the standard tone. Cocaine's effects were assessed once or twice weekly by giving an intramuscular injection of cocaine hydrochloride (0.01-0.56 mg/kg) immediately prior to performing the task and by examining correct detections and reaction times for each tone following drug administration. Cocaine impaired tone discriminability, with greater impairments occurring for those tones that were more similar in frequency to the standard tone. Cocaine's perceptual effects occurred within 20-70 min following drug administration. Cocaine also impaired or facilitated the speed of responding to auditory stimuli, depending upon the drug dose and subject. The results demonstrate that cocaine can impair auditory discriminations involving simple tones, as well as speech sounds, and further supports the suggestion that cocaine's effects are focused on CNS mechanisms related to the use of pitch cues.

Original languageEnglish (US)
Pages (from-to)825-833
Number of pages9
JournalPharmacology Biochemistry and Behavior
Volume72
Issue number4
DOIs
StatePublished - 2002

Fingerprint

Papio
Cocaine
Phonetics
Acoustic waves
Pharmaceutical Preparations
Discrimination (Psychology)
Intramuscular Injections
Acoustics
Reaction Time
Cues

Keywords

  • Auditory perception
  • Baboon
  • Cocaine
  • Discrimination
  • Lever release
  • Reaction time

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Cocaine's effects on the discrimination of simple and complex auditory stimuli by baboons. / Hienz, Robert D; Weed, Michael R.; Zarcone, Troy J.; Brady, Joseph V.

In: Pharmacology Biochemistry and Behavior, Vol. 72, No. 4, 2002, p. 825-833.

Research output: Contribution to journalArticle

Hienz, Robert D ; Weed, Michael R. ; Zarcone, Troy J. ; Brady, Joseph V. / Cocaine's effects on the discrimination of simple and complex auditory stimuli by baboons. In: Pharmacology Biochemistry and Behavior. 2002 ; Vol. 72, No. 4. pp. 825-833.
@article{17165cf0abca4574bd8dffbd44799703,
title = "Cocaine's effects on the discrimination of simple and complex auditory stimuli by baboons",
abstract = "The effects of cocaine on tone frequency discriminations by baboons were examined and compared with previous data for more complex acoustic stimuli (speech sounds) to see if cocaine's perceptual effects on these discriminations depends upon the type of stimulus employed (i.e., tones vs. speech sounds). Baboons pressed a lever to produce one repeating {"}standard{"} tone and released the lever only when one of four other {"}comparison{"} tones occasionally occurred in place of the standard tone. Cocaine's effects were assessed once or twice weekly by giving an intramuscular injection of cocaine hydrochloride (0.01-0.56 mg/kg) immediately prior to performing the task and by examining correct detections and reaction times for each tone following drug administration. Cocaine impaired tone discriminability, with greater impairments occurring for those tones that were more similar in frequency to the standard tone. Cocaine's perceptual effects occurred within 20-70 min following drug administration. Cocaine also impaired or facilitated the speed of responding to auditory stimuli, depending upon the drug dose and subject. The results demonstrate that cocaine can impair auditory discriminations involving simple tones, as well as speech sounds, and further supports the suggestion that cocaine's effects are focused on CNS mechanisms related to the use of pitch cues.",
keywords = "Auditory perception, Baboon, Cocaine, Discrimination, Lever release, Reaction time",
author = "Hienz, {Robert D} and Weed, {Michael R.} and Zarcone, {Troy J.} and Brady, {Joseph V.}",
year = "2002",
doi = "10.1016/S0091-3057(02)00775-X",
language = "English (US)",
volume = "72",
pages = "825--833",
journal = "Pharmacology, Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Cocaine's effects on the discrimination of simple and complex auditory stimuli by baboons

AU - Hienz, Robert D

AU - Weed, Michael R.

AU - Zarcone, Troy J.

AU - Brady, Joseph V.

PY - 2002

Y1 - 2002

N2 - The effects of cocaine on tone frequency discriminations by baboons were examined and compared with previous data for more complex acoustic stimuli (speech sounds) to see if cocaine's perceptual effects on these discriminations depends upon the type of stimulus employed (i.e., tones vs. speech sounds). Baboons pressed a lever to produce one repeating "standard" tone and released the lever only when one of four other "comparison" tones occasionally occurred in place of the standard tone. Cocaine's effects were assessed once or twice weekly by giving an intramuscular injection of cocaine hydrochloride (0.01-0.56 mg/kg) immediately prior to performing the task and by examining correct detections and reaction times for each tone following drug administration. Cocaine impaired tone discriminability, with greater impairments occurring for those tones that were more similar in frequency to the standard tone. Cocaine's perceptual effects occurred within 20-70 min following drug administration. Cocaine also impaired or facilitated the speed of responding to auditory stimuli, depending upon the drug dose and subject. The results demonstrate that cocaine can impair auditory discriminations involving simple tones, as well as speech sounds, and further supports the suggestion that cocaine's effects are focused on CNS mechanisms related to the use of pitch cues.

AB - The effects of cocaine on tone frequency discriminations by baboons were examined and compared with previous data for more complex acoustic stimuli (speech sounds) to see if cocaine's perceptual effects on these discriminations depends upon the type of stimulus employed (i.e., tones vs. speech sounds). Baboons pressed a lever to produce one repeating "standard" tone and released the lever only when one of four other "comparison" tones occasionally occurred in place of the standard tone. Cocaine's effects were assessed once or twice weekly by giving an intramuscular injection of cocaine hydrochloride (0.01-0.56 mg/kg) immediately prior to performing the task and by examining correct detections and reaction times for each tone following drug administration. Cocaine impaired tone discriminability, with greater impairments occurring for those tones that were more similar in frequency to the standard tone. Cocaine's perceptual effects occurred within 20-70 min following drug administration. Cocaine also impaired or facilitated the speed of responding to auditory stimuli, depending upon the drug dose and subject. The results demonstrate that cocaine can impair auditory discriminations involving simple tones, as well as speech sounds, and further supports the suggestion that cocaine's effects are focused on CNS mechanisms related to the use of pitch cues.

KW - Auditory perception

KW - Baboon

KW - Cocaine

KW - Discrimination

KW - Lever release

KW - Reaction time

UR - http://www.scopus.com/inward/record.url?scp=0035991282&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035991282&partnerID=8YFLogxK

U2 - 10.1016/S0091-3057(02)00775-X

DO - 10.1016/S0091-3057(02)00775-X

M3 - Article

VL - 72

SP - 825

EP - 833

JO - Pharmacology, Biochemistry and Behavior

JF - Pharmacology, Biochemistry and Behavior

SN - 0091-3057

IS - 4

ER -