Cocaine-induced suppression of renin secretion is partially mediated by serotonergic mechanisms

Andrew D. Levy, Peter A. Rittenhouse, Qian Li, Janice E. Kerr, Theresa M. Cabrera, George Battaglia, Louis D. Van De Kar

Research output: Contribution to journalArticlepeer-review

Abstract

Acute cocaine reduces renin secretion. To determine whether serotonergic neurons mediate this effect, male Sprague-Dawley rats received the serotonin (5-HT) neurotoxin 5,7-dihydroxytryptamine (75 Ωg/side, ICV) 2 weeks prior to cocaine injections (3.75-15 mg/kg, IP. 5-HT lesions attenuated the cocaine-induced reduction of plasma renin concentration (PRC), suggesting a partial 5-HT role. To determine which receptors mediate this response, rats were pretreated with the partial 5-HT1A agonist 8-[2-[4-(2-methoxyphenyl)-l-piperazinyl]ethyl]-8-azaspirol-[4,5]-decane-7,9- dione (BMY 7378) (1 mg/kg, SC), the 5-HT1C/5-HT2 antagonist ritanserin (0.1 mg/kg, SC), or the α2/5-HT1A antagonist yohimbine (1 mg/kg, SC) prior to cocaine. None of the antagonists altered the cocaine-induced suppression of PRC, although BMY 7378 and yohimbine elevated PRC. The data suggest that cocaine's effect is partially mediated by a serotonergic mechanism, but do not support a role for 5-HT1A receptors, 5-HT2/5-HT1C receptors, or α2-adrenoceptors in mediating the suppressive effect of cocaine on renin secretion.

Original languageEnglish (US)
Pages (from-to)481-486
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume42
Issue number3
DOIs
StatePublished - Jul 1992
Externally publishedYes

Keywords

  • 5,7-Dihydroxtryptamine
  • BMY 7378
  • Cocaine
  • Rat
  • Renin
  • Serotonin
  • Yohimbine

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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