TY - JOUR
T1 - Cocaine-induced suppression of renin secretion is mediated in the brain
T2 - Investigation of cardiovascular and local anesthetic mechanisms
AU - Van De Kar, Louis D.
AU - Levy, Andrew D.
AU - Rittenhouse, Peter A.
AU - Li, Qian
AU - Alvarez Sanz, Maria C.
AU - Yracheta, Joseph
AU - Kunimoto, Kayoko
PY - 1992/5
Y1 - 1992/5
N2 - Acute cocaine reduces renin secretion. To determine a peripheral versus central site of action, intracerebroventricular (ICV) versus intraperitoneal (IP) injections of cocaine were compared. Cocaine was more potent reducing plasma renin activity (PRA) and concentration (PRC) when injected ICV (0.050 mg/kg) than IP (5 mg/kg), suggesting a central site of action. Furthermore, addition of cocaine (10-4 M) to kidney slices in vitro did not influence renin release, indicating that cocaine does not suppress renin secretion by acting directly in the kidney. We also investigated whether the hypertensive or local anesthetic properties of cocaine mediate its inhibition of renin secretion. Therefore, we compared the cardiovascular and endocrine effects of cocaine with those of the local anesthetic drug procaine. Both cocaine and procaine (500 μg/kg, ICV) produced rapid and short-term increases in blood pressure, but cocaine decreased PRC whereas procaine increased PRC. Intra-arterial (IA) and IP injections of cocaine also reduced PRC whereas procaine had no effect (IA) or elevated PRC (IP). Together, the data suggest that cocaine decreases renin secretion by acting in the brain. It is not likely that the cardiovascular or local anesthetic actions of cocaine are the main cause of its suppressive effect on renin secretion.
AB - Acute cocaine reduces renin secretion. To determine a peripheral versus central site of action, intracerebroventricular (ICV) versus intraperitoneal (IP) injections of cocaine were compared. Cocaine was more potent reducing plasma renin activity (PRA) and concentration (PRC) when injected ICV (0.050 mg/kg) than IP (5 mg/kg), suggesting a central site of action. Furthermore, addition of cocaine (10-4 M) to kidney slices in vitro did not influence renin release, indicating that cocaine does not suppress renin secretion by acting directly in the kidney. We also investigated whether the hypertensive or local anesthetic properties of cocaine mediate its inhibition of renin secretion. Therefore, we compared the cardiovascular and endocrine effects of cocaine with those of the local anesthetic drug procaine. Both cocaine and procaine (500 μg/kg, ICV) produced rapid and short-term increases in blood pressure, but cocaine decreased PRC whereas procaine increased PRC. Intra-arterial (IA) and IP injections of cocaine also reduced PRC whereas procaine had no effect (IA) or elevated PRC (IP). Together, the data suggest that cocaine decreases renin secretion by acting in the brain. It is not likely that the cardiovascular or local anesthetic actions of cocaine are the main cause of its suppressive effect on renin secretion.
KW - Blood pressure
KW - Cocaine
KW - Intracerebroventricular injections
KW - Local anesthetic
KW - Procaine
KW - Renin
UR - http://www.scopus.com/inward/record.url?scp=0026639441&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026639441&partnerID=8YFLogxK
U2 - 10.1016/0361-9230(92)90270-8
DO - 10.1016/0361-9230(92)90270-8
M3 - Article
C2 - 1617466
AN - SCOPUS:0026639441
SN - 0361-9230
VL - 28
SP - 837
EP - 842
JO - Brain Research Bulletin
JF - Brain Research Bulletin
IS - 5
ER -