Abstract
We examined the effects of cocaine hydrochloride (40 mg intravenously) on regional cerebral metabolic rates for glucose and on subjective self-reports of eight polydrug abusers in a double-blind, placebo-controlled, crossover study. The regional cerebral metabolic rate for glucose was measured by the [fluorine 18]-fluorodeoxyglucose method, using positron emission tomography. With eyes covered, subjects listened to a tape that presented white noise, “beep” prompts, and questions about subjective effects of cocaine or saline. Cocaine produced euphoria and reduced glucose utilization globally (mean reduction, 14%). Twenty-six of 29 brain regions (all neocortical areas, basal ganglia, portions of the hippocampal formation, thalamus, and midbrain) showed significant decrements (5% to 26%) in the regional cerebral metabolic rate for glucose. No significant effects of cocaine were observed in the pons, the cerebellar cortex, or the vermis. Right-greater-than-left hemispheric asymmetry of regional cerebral metabolic rates for glucose occurred in the lateral thalamus. The findings demonstrate that reduced cerebral metabolism is associated with cocaine-induced euphoria.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 567-574 |
| Number of pages | 8 |
| Journal | Archives of General Psychiatry |
| Volume | 47 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1990 |
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ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Psychiatry and Mental health
Cite this
Cocaine-Induced Redoppuction of Glucose Utilization in Human Brain : A Study Using Positron Emission Tomography and [Fluorine 18]-Fluorodeoxyglucose. / London, Edythe D.; Cascella, Nicola G.; Wong, Dean Foster; Phillips, Robert L.; Dannals, Robert F; Links, Jonathan M; Herning, Ronald; Grayson, Roger; Jaffe, Jerome H.; Wagner, Henry N.
In: Archives of General Psychiatry, Vol. 47, No. 6, 1990, p. 567-574.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cocaine-Induced Redoppuction of Glucose Utilization in Human Brain
T2 - A Study Using Positron Emission Tomography and [Fluorine 18]-Fluorodeoxyglucose
AU - London, Edythe D.
AU - Cascella, Nicola G.
AU - Wong, Dean Foster
AU - Phillips, Robert L.
AU - Dannals, Robert F
AU - Links, Jonathan M
AU - Herning, Ronald
AU - Grayson, Roger
AU - Jaffe, Jerome H.
AU - Wagner, Henry N.
PY - 1990
Y1 - 1990
N2 - We examined the effects of cocaine hydrochloride (40 mg intravenously) on regional cerebral metabolic rates for glucose and on subjective self-reports of eight polydrug abusers in a double-blind, placebo-controlled, crossover study. The regional cerebral metabolic rate for glucose was measured by the [fluorine 18]-fluorodeoxyglucose method, using positron emission tomography. With eyes covered, subjects listened to a tape that presented white noise, “beep” prompts, and questions about subjective effects of cocaine or saline. Cocaine produced euphoria and reduced glucose utilization globally (mean reduction, 14%). Twenty-six of 29 brain regions (all neocortical areas, basal ganglia, portions of the hippocampal formation, thalamus, and midbrain) showed significant decrements (5% to 26%) in the regional cerebral metabolic rate for glucose. No significant effects of cocaine were observed in the pons, the cerebellar cortex, or the vermis. Right-greater-than-left hemispheric asymmetry of regional cerebral metabolic rates for glucose occurred in the lateral thalamus. The findings demonstrate that reduced cerebral metabolism is associated with cocaine-induced euphoria.
AB - We examined the effects of cocaine hydrochloride (40 mg intravenously) on regional cerebral metabolic rates for glucose and on subjective self-reports of eight polydrug abusers in a double-blind, placebo-controlled, crossover study. The regional cerebral metabolic rate for glucose was measured by the [fluorine 18]-fluorodeoxyglucose method, using positron emission tomography. With eyes covered, subjects listened to a tape that presented white noise, “beep” prompts, and questions about subjective effects of cocaine or saline. Cocaine produced euphoria and reduced glucose utilization globally (mean reduction, 14%). Twenty-six of 29 brain regions (all neocortical areas, basal ganglia, portions of the hippocampal formation, thalamus, and midbrain) showed significant decrements (5% to 26%) in the regional cerebral metabolic rate for glucose. No significant effects of cocaine were observed in the pons, the cerebellar cortex, or the vermis. Right-greater-than-left hemispheric asymmetry of regional cerebral metabolic rates for glucose occurred in the lateral thalamus. The findings demonstrate that reduced cerebral metabolism is associated with cocaine-induced euphoria.
UR - http://www.scopus.com/inward/record.url?scp=0025294009&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025294009&partnerID=8YFLogxK
U2 - 10.1001/archpsyc.1990.01810180067010
DO - 10.1001/archpsyc.1990.01810180067010
M3 - Article
C2 - 2350209
AN - SCOPUS:0025294009
VL - 47
SP - 567
EP - 574
JO - JAMA Psychiatry
JF - JAMA Psychiatry
SN - 2168-622X
IS - 6
ER -