Cocaine-induced deficits in ACTH and corticosterone responses in female rat progeny

Theresa M. Cabrera, Andrew D. Levy, Qian Li, Louis D. van de Kar, George Battaglia

Research output: Contribution to journalArticle

Abstract

The objective of this study was to determine whether prenatal exposure to cocaine could produce functional changes in central serotonergic systems mediating neuroendocrine responses in female progeny. Pregnant rats were administered either saline or (-) cocaine (15 mg/kg, SC b.i.d.) from gestational day 13-20. Progeny were fostered to nontreated lactating dams at birth. Central serotonergic function was determined by the ability of a serotonin releaser, p-chloroamphetamine (PCA), to stimulate plasma adrenocorticotropin (ACTH), corticosterone, and renin secretion in female progeny at postnatal day (PD) 30. Prenatal cocaine did not alter basal levels of ACTH, corticosterone, or renin. In contrast, ACTH and corticosterone responses to the 5-HT releaser PCA were significantly attenuated (-28 to 43%) in cocaine progeny, while the renin response to PCA was unaffected. These data suggest that cocaine administration during pregnancy can produce long-term selective alterations in neuroendocrine responses mediated by central serotonergic systems in prepubescent female progeny.

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalBrain Research Bulletin
Volume34
Issue number2
DOIs
StatePublished - 1994
Externally publishedYes

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Corticosterone
Cocaine
Adrenocorticotropic Hormone
p-Chloroamphetamine
Renin
Serotonin
Neurosecretory Systems
Parturition
Pregnancy

Keywords

  • Adrenocorticotropin
  • Cocaine
  • Female
  • In utero
  • p-Chloroamphetmaine Serotonin releasing drugs Corticosterone Rat
  • Prenatal
  • Serotonin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cocaine-induced deficits in ACTH and corticosterone responses in female rat progeny. / Cabrera, Theresa M.; Levy, Andrew D.; Li, Qian; van de Kar, Louis D.; Battaglia, George.

In: Brain Research Bulletin, Vol. 34, No. 2, 1994, p. 93-97.

Research output: Contribution to journalArticle

Cabrera, Theresa M. ; Levy, Andrew D. ; Li, Qian ; van de Kar, Louis D. ; Battaglia, George. / Cocaine-induced deficits in ACTH and corticosterone responses in female rat progeny. In: Brain Research Bulletin. 1994 ; Vol. 34, No. 2. pp. 93-97.
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