Cocaine-induced cocaine craving

Jerome H. Jaffe, Nicola G. Cascella, Karen M. Kumor, Michael A. Sherer

Research output: Contribution to journalArticlepeer-review

Abstract

In nine experienced users of cocaine, we examined the urge to use cocaine or other drugs following a 40 mg dose of intravenous (IV) cocaine with and without oral pretreatment with 2.5 mg bromocriptine. The urge to use cocaine was assessed with a questionnaire constructed to assess both "wanting" and "craving" for cocaine or other drugs. Fifteen minutes after the administration of cocaine (but not after placebo), subjects' ratings for both drug "wanting" and drug "craving" were significantly increased. Our results provide a laboratory demonstration of cocaine-induced increases in the urge to use drugs in humans. The findings, stressing the role of internal stimuli associated with drug administration, suggest the possibility of distinguishing among related, but perhaps distinct, components of the fluctuating levels of motivation to reuse drugs.

Original languageEnglish (US)
Pages (from-to)59-64
Number of pages6
JournalPsychopharmacology
Volume97
Issue number1
DOIs
StatePublished - Jan 1989
Externally publishedYes

Keywords

  • Bromocriptine
  • Cocaine
  • Craving
  • Dopamine
  • Drug abuse

ASJC Scopus subject areas

  • Pharmacology

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