Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula

Frank J. Meye, Kristina Valentinova, Salvatore Lecca, Lucile Marion-Poll, Matthieu J. Maroteaux, Stefano Musardo, Imane Moutkine, Fabrizio Gardoni, Richard L Huganir, François Georges, Manuel Mameli

Research output: Contribution to journalArticle

Abstract

Addictive substances mediate positive and negative states promoting persistent drug use. However, substrates for aversive effects of drugs remain elusive. We found that, in mouse lateral habenula (LHb) neurons targeting the rostromedial tegmental nucleus, cocaine enhanced glutamatergic transmission, reduced K + currents and increased excitability. GluA1 trafficking in LHb was instrumental for these cocaine-evoked modifications and drug-driven aversive behaviors. Altogether, our results suggest that long-lasting adaptations in LHb shape negative symptoms after drug taking.

Original languageEnglish (US)
Pages (from-to)376-380
Number of pages5
JournalNature Neuroscience
Volume18
Issue number3
DOIs
StatePublished - Mar 27 2015

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Habenula
AMPA Receptors
Cocaine
Pharmaceutical Preparations
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Meye, F. J., Valentinova, K., Lecca, S., Marion-Poll, L., Maroteaux, M. J., Musardo, S., ... Mameli, M. (2015). Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula. Nature Neuroscience, 18(3), 376-380. https://doi.org/10.1038/nn.3923

Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula. / Meye, Frank J.; Valentinova, Kristina; Lecca, Salvatore; Marion-Poll, Lucile; Maroteaux, Matthieu J.; Musardo, Stefano; Moutkine, Imane; Gardoni, Fabrizio; Huganir, Richard L; Georges, François; Mameli, Manuel.

In: Nature Neuroscience, Vol. 18, No. 3, 27.03.2015, p. 376-380.

Research output: Contribution to journalArticle

Meye, FJ, Valentinova, K, Lecca, S, Marion-Poll, L, Maroteaux, MJ, Musardo, S, Moutkine, I, Gardoni, F, Huganir, RL, Georges, F & Mameli, M 2015, 'Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula', Nature Neuroscience, vol. 18, no. 3, pp. 376-380. https://doi.org/10.1038/nn.3923
Meye FJ, Valentinova K, Lecca S, Marion-Poll L, Maroteaux MJ, Musardo S et al. Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula. Nature Neuroscience. 2015 Mar 27;18(3):376-380. https://doi.org/10.1038/nn.3923
Meye, Frank J. ; Valentinova, Kristina ; Lecca, Salvatore ; Marion-Poll, Lucile ; Maroteaux, Matthieu J. ; Musardo, Stefano ; Moutkine, Imane ; Gardoni, Fabrizio ; Huganir, Richard L ; Georges, François ; Mameli, Manuel. / Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula. In: Nature Neuroscience. 2015 ; Vol. 18, No. 3. pp. 376-380.
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