Cocaine and metabolites urinary excretion after controlled smoked administration

Marilyn A. Huestis, W. David Darwin, Eric Shimomura, Shairose A. Lalani, Daniel V. Trinidad, Amanda J. Jenkins, Edward J. Cone, Aaron J. Jacobs, Michael L. Smith, Buddha D. Paul

Research output: Contribution to journalArticlepeer-review

Abstract

Understanding cocaine and metabolites urinary excretion following smoking is important for interpretation of urine test results in judicial, workplace and treatment settings. In National Institute on Drug Abuse approved studies on a secure research unit, six subjects smoked placebo, 10, 20, and 40 mg cocaine with a precise dose delivery device and six different subjects smoked 42 mg cocaine in a glass pipe. Urine specimens (n= 700) were collected for up to seven days and analyzed for cocaine (COC), benzoylecgonine (BE), ecgonine methylester (EME), m-hydroxybenzoylecgonine (mOHBE), p-hydroxybenzoylecgonine (pOHBE), norbenzoylecgonine (NBE), and ecgonine (EC) by gas chromatography-mass spectrometry. Results (mean ± SE) for the 40-mg precise delivery doses are as follows: (Table Presented) Mean Cmax for all analytes linearly increased with increasing dose. Tmax was not dose-dependent. All metabolites were detected in some subjects within 2 h. EC concentrations were significantly higher after smoked cocaine in a precise delivery coil compared to a glass "crack" pipe.

Original languageEnglish (US)
Pages (from-to)462-468
Number of pages7
JournalJournal of analytical toxicology
Volume31
Issue number8
DOIs
StatePublished - Oct 2007

ASJC Scopus subject areas

  • Analytical Chemistry
  • Environmental Chemistry
  • Toxicology
  • Health, Toxicology and Mutagenesis
  • Chemical Health and Safety

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