Cocaine and metabolites urinary excretion after controlled smoked administration

Marilyn A. Huestis; W. David Darwin; Eric Shimomura; Shairose A. Lalani; Daniel V. Trinidad; Amanda J. Jenkins; Edward J. Cone; Aaron J. Jacobs; Michael L. Smith; Buddha D. Paul

doi:10.1093/jat/31.8.462

Cocaine and metabolites urinary excretion after controlled smoked administration

Marilyn A. Huestis, W. David Darwin, Eric Shimomura, Shairose A. Lalani, Daniel V. Trinidad, Amanda J. Jenkins, Edward J. Cone, Aaron J. Jacobs, Michael L. Smith, Buddha D. Paul

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Understanding cocaine and metabolites urinary excretion following smoking is important for interpretation of urine test results in judicial, workplace and treatment settings. In National Institute on Drug Abuse approved studies on a secure research unit, six subjects smoked placebo, 10, 20, and 40 mg cocaine with a precise dose delivery device and six different subjects smoked 42 mg cocaine in a glass pipe. Urine specimens (n= 700) were collected for up to seven days and analyzed for cocaine (COC), benzoylecgonine (BE), ecgonine methylester (EME), m-hydroxybenzoylecgonine (mOHBE), p-hydroxybenzoylecgonine (pOHBE), norbenzoylecgonine (NBE), and ecgonine (EC) by gas chromatography-mass spectrometry. Results (mean ± SE) for the 40-mg precise delivery doses are as follows: (Table Presented) Mean C_max for all analytes linearly increased with increasing dose. T_max was not dose-dependent. All metabolites were detected in some subjects within 2 h. EC concentrations were significantly higher after smoked cocaine in a precise delivery coil compared to a glass "crack" pipe.

Original language	English (US)
Pages (from-to)	462-468
Number of pages	7
Journal	Journal of analytical toxicology
Volume	31
Issue number	8
DOIs	https://doi.org/10.1093/jat/31.8.462
State	Published - Oct 2007
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Environmental Chemistry
Toxicology
Health, Toxicology and Mutagenesis
Chemical Health and Safety

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title = "Cocaine and metabolites urinary excretion after controlled smoked administration",

abstract = "Understanding cocaine and metabolites urinary excretion following smoking is important for interpretation of urine test results in judicial, workplace and treatment settings. In National Institute on Drug Abuse approved studies on a secure research unit, six subjects smoked placebo, 10, 20, and 40 mg cocaine with a precise dose delivery device and six different subjects smoked 42 mg cocaine in a glass pipe. Urine specimens (n= 700) were collected for up to seven days and analyzed for cocaine (COC), benzoylecgonine (BE), ecgonine methylester (EME), m-hydroxybenzoylecgonine (mOHBE), p-hydroxybenzoylecgonine (pOHBE), norbenzoylecgonine (NBE), and ecgonine (EC) by gas chromatography-mass spectrometry. Results (mean ± SE) for the 40-mg precise delivery doses are as follows: (Table Presented) Mean Cmax for all analytes linearly increased with increasing dose. Tmax was not dose-dependent. All metabolites were detected in some subjects within 2 h. EC concentrations were significantly higher after smoked cocaine in a precise delivery coil compared to a glass {"}crack{"} pipe.",

author = "Huestis, {Marilyn A.} and Darwin, {W. David} and Eric Shimomura and Lalani, {Shairose A.} and Trinidad, {Daniel V.} and Jenkins, {Amanda J.} and Cone, {Edward J.} and Jacobs, {Aaron J.} and Smith, {Michael L.} and Paul, {Buddha D.}",

note = "Funding Information: The authors thank the American Registry of Pathology and the National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program for support.",

year = "2007",

month = oct,

doi = "10.1093/jat/31.8.462",

language = "English (US)",

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T1 - Cocaine and metabolites urinary excretion after controlled smoked administration

AU - Huestis, Marilyn A.

AU - Darwin, W. David

AU - Shimomura, Eric

AU - Lalani, Shairose A.

AU - Trinidad, Daniel V.

AU - Jenkins, Amanda J.

AU - Cone, Edward J.

AU - Jacobs, Aaron J.

AU - Smith, Michael L.

AU - Paul, Buddha D.

N1 - Funding Information: The authors thank the American Registry of Pathology and the National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program for support.

PY - 2007/10

Y1 - 2007/10

N2 - Understanding cocaine and metabolites urinary excretion following smoking is important for interpretation of urine test results in judicial, workplace and treatment settings. In National Institute on Drug Abuse approved studies on a secure research unit, six subjects smoked placebo, 10, 20, and 40 mg cocaine with a precise dose delivery device and six different subjects smoked 42 mg cocaine in a glass pipe. Urine specimens (n= 700) were collected for up to seven days and analyzed for cocaine (COC), benzoylecgonine (BE), ecgonine methylester (EME), m-hydroxybenzoylecgonine (mOHBE), p-hydroxybenzoylecgonine (pOHBE), norbenzoylecgonine (NBE), and ecgonine (EC) by gas chromatography-mass spectrometry. Results (mean ± SE) for the 40-mg precise delivery doses are as follows: (Table Presented) Mean Cmax for all analytes linearly increased with increasing dose. Tmax was not dose-dependent. All metabolites were detected in some subjects within 2 h. EC concentrations were significantly higher after smoked cocaine in a precise delivery coil compared to a glass "crack" pipe.

AB - Understanding cocaine and metabolites urinary excretion following smoking is important for interpretation of urine test results in judicial, workplace and treatment settings. In National Institute on Drug Abuse approved studies on a secure research unit, six subjects smoked placebo, 10, 20, and 40 mg cocaine with a precise dose delivery device and six different subjects smoked 42 mg cocaine in a glass pipe. Urine specimens (n= 700) were collected for up to seven days and analyzed for cocaine (COC), benzoylecgonine (BE), ecgonine methylester (EME), m-hydroxybenzoylecgonine (mOHBE), p-hydroxybenzoylecgonine (pOHBE), norbenzoylecgonine (NBE), and ecgonine (EC) by gas chromatography-mass spectrometry. Results (mean ± SE) for the 40-mg precise delivery doses are as follows: (Table Presented) Mean Cmax for all analytes linearly increased with increasing dose. Tmax was not dose-dependent. All metabolites were detected in some subjects within 2 h. EC concentrations were significantly higher after smoked cocaine in a precise delivery coil compared to a glass "crack" pipe.

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Cocaine and metabolites urinary excretion after controlled smoked administration

Abstract

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