Cocaine and metabolite elimination patterns in chronic cocaine users during cessation: Plasma and saliva analysis

E. T. Moolchan, E. J. Cone, A. Wstadik, M. A. Huestis, K. L. Preston

Research output: Contribution to journalArticle

Abstract

Several reports suggest a prolonged elimination of cocaine and metabolites after chronic use compared with single or occasional use. This study was designed to measure the half-lives of cocaine in plasma and saliva of individuals who consumed cocaine on a frequent basis. The disposition and elimination patterns of cocaine and metabolites in the body fluids of chronic high-dose cocaine users during acute cessation of use were investigated. Plasma and saliva specimens were collected over a 12-h period during cessation and analyzed by gas chromatography-mass spectrometry. Pharmacokinetic parameters were derived by noncompartmental analysis of plasma and saliva data. Results indicated a cocaine terminal T( 1/2 ) of 3.8 h in plasma and 7.9 h in saliva. The terminal T( 1/2 ) of benzoylecgonine was 6.6 h in plasma and 9.2 h in saliva. Compared with prior studies of acute low-dose cocaine administration, these findings suggest that cocaine's half-life is longer in active street users than in occasional users though the half-life of its main metabolite benzoylecgonine remains similar (as do cocaine saliva-to-plasma ratios). Thus, regular use of cocaine appears to alter the disposition and elimination of cocaine when compared to single or occasional use.

Original languageEnglish (US)
Pages (from-to)458-466
Number of pages9
JournalJournal of Analytical Toxicology
Volume24
Issue number7
StatePublished - 2000
Externally publishedYes

Fingerprint

saliva
Metabolites
Cocaine
Saliva
metabolite
Plasmas
plasma
half life
body fluid
Pharmacokinetics
Body fluids
Half-Life
Gas chromatography
Mass spectrometry
analysis
gas chromatography
mass spectrometry
Body Fluids
Gas Chromatography-Mass Spectrometry

ASJC Scopus subject areas

  • Analytical Chemistry
  • Health, Toxicology and Mutagenesis
  • Toxicology

Cite this

Moolchan, E. T., Cone, E. J., Wstadik, A., Huestis, M. A., & Preston, K. L. (2000). Cocaine and metabolite elimination patterns in chronic cocaine users during cessation: Plasma and saliva analysis. Journal of Analytical Toxicology, 24(7), 458-466.

Cocaine and metabolite elimination patterns in chronic cocaine users during cessation : Plasma and saliva analysis. / Moolchan, E. T.; Cone, E. J.; Wstadik, A.; Huestis, M. A.; Preston, K. L.

In: Journal of Analytical Toxicology, Vol. 24, No. 7, 2000, p. 458-466.

Research output: Contribution to journalArticle

Moolchan, ET, Cone, EJ, Wstadik, A, Huestis, MA & Preston, KL 2000, 'Cocaine and metabolite elimination patterns in chronic cocaine users during cessation: Plasma and saliva analysis', Journal of Analytical Toxicology, vol. 24, no. 7, pp. 458-466.
Moolchan, E. T. ; Cone, E. J. ; Wstadik, A. ; Huestis, M. A. ; Preston, K. L. / Cocaine and metabolite elimination patterns in chronic cocaine users during cessation : Plasma and saliva analysis. In: Journal of Analytical Toxicology. 2000 ; Vol. 24, No. 7. pp. 458-466.
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