Cobalt-catalyzed asymmetric cyclopropanation of electron-deficient olefins

Ying Chen, Joshua V. Ruppel, X. Peter Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

The cobalt(II) complex of a D2-symmetric chiral porphyrin [Co(1)] is an effective catalyst for asymmetric cyclopropanation of electron-deficient olefins, including α,β-unsaturated esters, amides, ketones, and nitriles. Due to the absence of dimerization of diazo compounds, the catalytic reactions can be performed in one-pot protocol using olefins as the limiting reagent, forming the desired electrophilic cyclopropane derivatives in high yields and selectivities under mild conditions. In most cases, both excellent diastereo- and enantioselectivity were achieved.

Original languageEnglish (US)
Pages (from-to)12074-12075
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number40
DOIs
StatePublished - Oct 10 2007

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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