Coats, Tethers, Rabs, and SNAREs Work Together to Mediate the Intracellular Destination of a Transport Vesicle

Huaqing Cai, Karin Reinisch, Susan Ferro-Novick

Research output: Contribution to journalArticlepeer-review

Abstract

Tethering factors have been shown to interact with Rabs and SNAREs and, more recently, with coat proteins. Coat proteins are required for cargo selection and membrane deformation to bud a transport vesicle from a donor compartment. It was once thought that a vesicle must uncoat before it recognizes its target membrane. However, recent findings have revealed a role for the coat in directing a vesicle to its correct intracellular destination. In this review we will discuss the literature that links coat proteins to vesicle targeting events.

Original languageEnglish (US)
Pages (from-to)671-682
Number of pages12
JournalDevelopmental Cell
Volume12
Issue number5
DOIs
StatePublished - May 8 2007
Externally publishedYes

ASJC Scopus subject areas

  • Developmental Biology

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