Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil

Camila Alexandrina Figueiredo, Maurício Lima Barreto, Neuza Maria Alcantara-Neves, Laura Cunha Rodrigues, Philip John Cooper, Alvaro A. Cruz, Lain Carlos Pontes-De-Carvalho, Denise C. Lemaire, Ryan Dos Santos Costa, Leila D. Amorim, Candelaria Vergara, Nicholas Rafaels, Li Gao, Cassandra Foster, Monica Campbell, Rasika A. Mathias, Kathleen C. Barnes

Research output: Contribution to journalArticle

Abstract

Background: Helminth infections are associated with protection against allergies. It is postulated that IL-10 production after helminth infection suppresses skin hypersensitivity and increases IgG4 production, protecting against allergies. Objective: We aimed to determine whether IL10 polymorphisms are associated with helminth infection and the risk of wheeze and allergy. Methods: Twelve IL10 single nucleotide polymorphisms were genotyped in 1353 children aged 4 to 11 years living in a poor urban area in Salvador, Brazil. Wheezing status, Ascaris lumbricoides and Trichuris trichiura infection, IL-10 production by peripheral blood leukocytes stimulated with A lumbricoides extract, serum total IgE levels, specific IgE levels, skin prick test responses to common aeroallergens, and IgG4 and IgE anti-A lumbricoides antibody levels were measured in all children. Association tests were performed by using logistic or linear regression when appropriate, including sex, age, helminth infection, and principal components for ancestry informative markers as covariates by using PLINK. Results: Allele G of marker rs3024496 was associated with the decreased production of IL-10 by peripheral blood leukocytes in response to A lumbricoides stimulation. Allele C of marker rs3024498 was negatively associated with helminth infection or its markers. Marker rs3024492 was positively associated with the risk of atopic wheeze, total IgE levels, and skin prick test responses to cockroach. Conclusions: Our findings suggest that IL10 polymorphisms might play a role in the production of IL-10, helminth infection, and allergy. We hypothesize that polymorphisms related to protection against helminths, which would offer an evolutionary advantage to subjects in the past, might be associated with increased risk of allergic diseases.

Original languageEnglish (US)
Pages (from-to)1683-1690
Number of pages8
JournalJournal of Allergy and Clinical Immunology
Volume131
Issue number6
DOIs
StatePublished - Jun 2013

Keywords

  • IL10
  • Social Changes Asthma and Allergy in Latin America
  • allergy
  • asthma
  • helminth infection
  • immune modulation
  • polymorphisms

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Figueiredo, C. A., Barreto, M. L., Alcantara-Neves, N. M., Rodrigues, L. C., Cooper, P. J., Cruz, A. A., Pontes-De-Carvalho, L. C., Lemaire, D. C., Dos Santos Costa, R., Amorim, L. D., Vergara, C., Rafaels, N., Gao, L., Foster, C., Campbell, M., Mathias, R. A., & Barnes, K. C. (2013). Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil. Journal of Allergy and Clinical Immunology, 131(6), 1683-1690. https://doi.org/10.1016/j.jaci.2012.10.043