TY - JOUR
T1 - Coarse particulate matter air pollution and hospital admissions for cardiovascular and respiratory diseases among medicare patients
AU - Peng, Roger D.
AU - Chang, Howard H.
AU - Bell, Michelle L.
AU - McDermott, Aidan
AU - Zeger, Scott L.
AU - Samet, Jonathan M.
AU - Dominici, Francesca
N1 - Funding Information:
Acknowledgment. This work was supported in part by a Grant-in Aid for Scientific Research (No. 02660075) from the Ministry ofEducation, Science and Culture ofJapan.
PY - 2008/5/14
Y1 - 2008/5/14
N2 - Context: Health risks of fine particulate matter of 2.5 μm or less in aerodynamic diameter (PM2.5) have been studied extensively over the last decade. Evidence concerning the health risks of the coarse fraction of greater than 2.5 μm and 10 μm or less in aerodynamic diameter (PM 10-2.5) is limited. Objective: To estimate risk of hospital admissions for cardiovascular and respiratory diseases associated with PM 10-2.5 exposure, controlling for PM2.5. Design, Setting, and Participants: Using a database assembled for 108 US counties with daily cardiovascular and respiratory disease admission rates, temperature and dew-point temperature, and PM10-2.5 and PM2.5 concentrations were calculated with monitoring data as an exposure surrogate from January 1, 1999, through December 31, 2005. Admission rates were constructed from the Medicare National Claims History Files, for a study population of approximately 12 million Medicare enrollees living on average 9 miles (14.4 km) from collocated pairs of PM10 and PM2.5 monitors. Main Outcome Measures: Daily counts of county-wide emergency hospital admissions for primary diagnoses of cardiovascular or respiratory disease. Results: There were 3.7 million cardiovascular disease and 1.4 million respiratory disease admissions. A 10-μg/m3 increase in PM 10-2.5 was associated with a 0.36% (95% posterior interval [PI], 0.05% to 0.68%) increase in cardiovascular disease admissions on the same day. However, when adjusted for PM2.5, the association was no longer statistically significant (0.25%; 95% PI, -0.11% to 0.60%). A 10-μg/m 3 increase in PM10-2.5 was associated with a nonstatistically significant unadjusted 0.33% (95% PI, -0.21% to 0.86%) increase in respiratory disease admissions and with a 0.26% (95% PI, -0.32% to 0.84%) increase in respiratory disease admissions when adjusted for PM2.5. The unadjusted associations of PM2.5 with cardiovascular and respiratory disease admissions were 0.71% (95% PI, 0.45%-0.96%) for same-day exposure and 0.44% (95% PI, 0.06% to 0.82%) for exposure 2 days before hospital admission. Conclusion: After adjustment for PM2.5, there were no statistically significant associations between coarse particulates and hospital admissions for cardiovascular and respiratory diseases.
AB - Context: Health risks of fine particulate matter of 2.5 μm or less in aerodynamic diameter (PM2.5) have been studied extensively over the last decade. Evidence concerning the health risks of the coarse fraction of greater than 2.5 μm and 10 μm or less in aerodynamic diameter (PM 10-2.5) is limited. Objective: To estimate risk of hospital admissions for cardiovascular and respiratory diseases associated with PM 10-2.5 exposure, controlling for PM2.5. Design, Setting, and Participants: Using a database assembled for 108 US counties with daily cardiovascular and respiratory disease admission rates, temperature and dew-point temperature, and PM10-2.5 and PM2.5 concentrations were calculated with monitoring data as an exposure surrogate from January 1, 1999, through December 31, 2005. Admission rates were constructed from the Medicare National Claims History Files, for a study population of approximately 12 million Medicare enrollees living on average 9 miles (14.4 km) from collocated pairs of PM10 and PM2.5 monitors. Main Outcome Measures: Daily counts of county-wide emergency hospital admissions for primary diagnoses of cardiovascular or respiratory disease. Results: There were 3.7 million cardiovascular disease and 1.4 million respiratory disease admissions. A 10-μg/m3 increase in PM 10-2.5 was associated with a 0.36% (95% posterior interval [PI], 0.05% to 0.68%) increase in cardiovascular disease admissions on the same day. However, when adjusted for PM2.5, the association was no longer statistically significant (0.25%; 95% PI, -0.11% to 0.60%). A 10-μg/m 3 increase in PM10-2.5 was associated with a nonstatistically significant unadjusted 0.33% (95% PI, -0.21% to 0.86%) increase in respiratory disease admissions and with a 0.26% (95% PI, -0.32% to 0.84%) increase in respiratory disease admissions when adjusted for PM2.5. The unadjusted associations of PM2.5 with cardiovascular and respiratory disease admissions were 0.71% (95% PI, 0.45%-0.96%) for same-day exposure and 0.44% (95% PI, 0.06% to 0.82%) for exposure 2 days before hospital admission. Conclusion: After adjustment for PM2.5, there were no statistically significant associations between coarse particulates and hospital admissions for cardiovascular and respiratory diseases.
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U2 - 10.1001/jama.299.18.2172
DO - 10.1001/jama.299.18.2172
M3 - Article
C2 - 18477784
AN - SCOPUS:43549085056
SN - 0098-7484
VL - 299
SP - 2172
EP - 2179
JO - JAMA
JF - JAMA
IS - 18
ER -