Coarse electrocorticographic decoding of ipsilateral reach in patients with brain lesions

Guy Hotson, Matthew S. Fifer, Soumyadipta Acharya, Heather L. Benz, William S Anderson, Nitish V Thakor, Nathan E Crone

Research output: Contribution to journalArticle

Abstract

In patients with unilateral upper limb paralysis from strokes and other brain lesions, strategies for functional recovery may eventually include brain-machine interfaces (BMIs) using control signals from residual sensorimotor systems in the damaged hemisphere. When voluntary movements of the contralateral limb are not possible due to brain pathology, initial training of such a BMI may require use of the unaffected ipsilateral limb. We conducted an offline investigation of the feasibility of decoding ipsilateral upper limb movements from electrocorticographic (ECoG) recordings in three patients with different lesions of sensorimotor systems associated with upper limb control. We found that the first principal component (PC) of unconstrained, naturalistic reaching movements of the upper limb could be decoded from ipsilateral ECoG using a linear model. ECoG signal features yielding the best decoding accuracy were different across subjects. Performance saturated with very few input features. Decoding performances of 0.77, 0.73, and 0.66 (median Pearson's r between the predicted and actual first PC of movement using nine signal features) were achieved in the three subjects. The performance achieved here with small numbers of electrodes and computationally simple decoding algorithms suggests that it may be possible to control a BMI using ECoG recorded from damaged sensorimotor brain systems.

Original languageEnglish (US)
Article numbere115236
JournalPLoS One
Volume9
Issue number12
DOIs
StatePublished - Dec 29 2014

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limbs (animal)
Brain-Computer Interfaces
Upper Extremity
lesions (animal)
Decoding
Brain
brain
Extremities
Paralysis
Linear Models
Electrodes
Stroke
Pathology
paralysis
stroke
electrodes
linear models
Recovery

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Coarse electrocorticographic decoding of ipsilateral reach in patients with brain lesions. / Hotson, Guy; Fifer, Matthew S.; Acharya, Soumyadipta; Benz, Heather L.; Anderson, William S; Thakor, Nitish V; Crone, Nathan E.

In: PLoS One, Vol. 9, No. 12, e115236, 29.12.2014.

Research output: Contribution to journalArticle

Hotson, Guy ; Fifer, Matthew S. ; Acharya, Soumyadipta ; Benz, Heather L. ; Anderson, William S ; Thakor, Nitish V ; Crone, Nathan E. / Coarse electrocorticographic decoding of ipsilateral reach in patients with brain lesions. In: PLoS One. 2014 ; Vol. 9, No. 12.
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