Coagulopathy in Acute Promyelocytic Leukemia: Can We Go Beyond Supportive Care?

Bryan Hambley, Ciprian Tomuleasa, Gabriel Ghiaur

Research output: Contribution to journalReview articlepeer-review

Abstract

Acute promyelocytic leukemia (APL) is characterized by frequent complications due to a distinct coagulopathy. While advances in treatments have improved long-term survival, hemorrhagic and thrombotic complications remain the most common causes of death and morbidity. Improved understanding of the mechanisms of the coagulopathy associated with APL may lead to therapeutic interventions to mitigate the risk of hemorrhage and thrombosis.

Original languageEnglish (US)
Article number722614
JournalFrontiers in Medicine
Volume8
DOIs
StatePublished - Aug 17 2021

Keywords

  • APL
  • ATRA
  • delayed bleeding
  • hemorrhage
  • hyperfibrinolysis
  • thrombosis

ASJC Scopus subject areas

  • Medicine(all)

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