Coagulopathy in Acute Promyelocytic Leukemia: Can We Go Beyond Supportive Care?

Bryan C. Hambley; Ciprian Tomuleasa; Gabriel Ghiaur

doi:10.3389/fmed.2021.722614

Coagulopathy in Acute Promyelocytic Leukemia: Can We Go Beyond Supportive Care?

Bryan C. Hambley, Ciprian Tomuleasa, Gabriel Ghiaur

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Acute promyelocytic leukemia (APL) is characterized by frequent complications due to a distinct coagulopathy. While advances in treatments have improved long-term survival, hemorrhagic and thrombotic complications remain the most common causes of death and morbidity. Improved understanding of the mechanisms of the coagulopathy associated with APL may lead to therapeutic interventions to mitigate the risk of hemorrhage and thrombosis.

Original language	English (US)
Article number	722614
Journal	Frontiers in Medicine
Volume	8
DOIs	https://doi.org/10.3389/fmed.2021.722614
State	Published - Aug 17 2021

Keywords

APL
ATRA
delayed bleeding
hemorrhage
hyperfibrinolysis
thrombosis

ASJC Scopus subject areas

General Medicine

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10.3389/fmed.2021.722614

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title = "Coagulopathy in Acute Promyelocytic Leukemia: Can We Go Beyond Supportive Care?",

abstract = "Acute promyelocytic leukemia (APL) is characterized by frequent complications due to a distinct coagulopathy. While advances in treatments have improved long-term survival, hemorrhagic and thrombotic complications remain the most common causes of death and morbidity. Improved understanding of the mechanisms of the coagulopathy associated with APL may lead to therapeutic interventions to mitigate the risk of hemorrhage and thrombosis.",

keywords = "APL, ATRA, delayed bleeding, hemorrhage, hyperfibrinolysis, thrombosis",

author = "Hambley, {Bryan C.} and Ciprian Tomuleasa and Gabriel Ghiaur",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Hambley, Tomuleasa and Ghiaur.",

year = "2021",

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doi = "10.3389/fmed.2021.722614",

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T2 - Can We Go Beyond Supportive Care?

AU - Hambley, Bryan C.

AU - Tomuleasa, Ciprian

AU - Ghiaur, Gabriel

PY - 2021/8/17

Y1 - 2021/8/17

N2 - Acute promyelocytic leukemia (APL) is characterized by frequent complications due to a distinct coagulopathy. While advances in treatments have improved long-term survival, hemorrhagic and thrombotic complications remain the most common causes of death and morbidity. Improved understanding of the mechanisms of the coagulopathy associated with APL may lead to therapeutic interventions to mitigate the risk of hemorrhage and thrombosis.

AB - Acute promyelocytic leukemia (APL) is characterized by frequent complications due to a distinct coagulopathy. While advances in treatments have improved long-term survival, hemorrhagic and thrombotic complications remain the most common causes of death and morbidity. Improved understanding of the mechanisms of the coagulopathy associated with APL may lead to therapeutic interventions to mitigate the risk of hemorrhage and thrombosis.

KW - APL

KW - ATRA

KW - delayed bleeding

KW - hemorrhage

KW - hyperfibrinolysis

KW - thrombosis

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M3 - Review article

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VL - 8

JO - Frontiers in Medicine

JF - Frontiers in Medicine

M1 - 722614

ER -

Coagulopathy in Acute Promyelocytic Leukemia: Can We Go Beyond Supportive Care?

Abstract

Keywords

ASJC Scopus subject areas

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