@article{89bf4e1ba31c495c90dcb735dd8a1a7b,
title = "Coagulopathy in Acute Promyelocytic Leukemia: Can We Go Beyond Supportive Care?",
abstract = "Acute promyelocytic leukemia (APL) is characterized by frequent complications due to a distinct coagulopathy. While advances in treatments have improved long-term survival, hemorrhagic and thrombotic complications remain the most common causes of death and morbidity. Improved understanding of the mechanisms of the coagulopathy associated with APL may lead to therapeutic interventions to mitigate the risk of hemorrhage and thrombosis.",
keywords = "APL, ATRA, delayed bleeding, hemorrhage, hyperfibrinolysis, thrombosis",
author = "Bryan Hambley and Ciprian Tomuleasa and Gabriel Ghiaur",
note = "Funding Information: CT was supported by an international grant awarded by the Novo Nordisk Haemophilia Foundation 2020–2021, Romania 3 grant – Strengthen haemophilia care in the north and establish a national registry in Romania, awarded to the Romanian Society of Hematology. CT also received funding from grants from the Romanian Ministry of Research and Innovation, CCCDI-UEFISCDI, Project No. PN-III-P4-ID-PCCF-2016-0112 within PNCDI III, for Young Research Teams 2020–2022 (Grant No. PNIII-P1-1.1-TE-2019-0271); PN-III-P1-1.1-TE-2016-0919, within PNCDI III, for Young Research Teams 2020–2022 (Babes Bolyai University); PNIII-CEI-BIM-PBE-2020-0016 within PNCDI I—a collaboration between Romania and Belgium (Wallonia) (Contract Number 13-BM/2020); and an international collaborative grant of the European Economic Space between Romania and Iceland 2020– 2022 (Grant No. 19-COP-0031). GG was funded by a grant from the Romanian Ministry of Research and Innovation - PN-III-P4-ID-PCE-2020-1118 within PNCDI IV, Projects for Exploratory Medicine. Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Hambley, Tomuleasa and Ghiaur.",
year = "2021",
month = aug,
day = "17",
doi = "10.3389/fmed.2021.722614",
language = "English (US)",
volume = "8",
journal = "Frontiers in Medicine",
issn = "2296-858X",
publisher = "Frontiers Media S. A.",
}