TY - JOUR
T1 - Coagulation and Complement Studies in Rocky Mountain Spotted Fever
AU - Fine, Douglas
AU - Mosher, Deane
AU - Yamada, Tadataka
AU - Burke, Donald
AU - Kenyon, Richard
PY - 1978/5
Y1 - 1978/5
N2 - A patient with laboratory-acquired Rocky Mountain spotted fever (RMSF) and concomitant influenza virus infection was studied from the third day of clinical illness. The course of his illness was marked by petechial rash, thrombocytopenia, and elevation of fibrin split products. No evidence of complement activation was observed. Plasma proteins were elevated in a pattern characteristic of the “acute phase reaction.” The patient recovered completely, and no vascular collapse or clinically important disseminated intravascular coagulation had developed. In febrile patients who had influenza or a clinically similar noninfluenzal respiratory syndrome, no changes in coagulation, complement, or plasma proteins developed. We conclude that aberrations in the patient's laboratory values reflected RMSF, and that complement played no critical role in his illness.
AB - A patient with laboratory-acquired Rocky Mountain spotted fever (RMSF) and concomitant influenza virus infection was studied from the third day of clinical illness. The course of his illness was marked by petechial rash, thrombocytopenia, and elevation of fibrin split products. No evidence of complement activation was observed. Plasma proteins were elevated in a pattern characteristic of the “acute phase reaction.” The patient recovered completely, and no vascular collapse or clinically important disseminated intravascular coagulation had developed. In febrile patients who had influenza or a clinically similar noninfluenzal respiratory syndrome, no changes in coagulation, complement, or plasma proteins developed. We conclude that aberrations in the patient's laboratory values reflected RMSF, and that complement played no critical role in his illness.
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U2 - 10.1001/archinte.1978.03630290043016
DO - 10.1001/archinte.1978.03630290043016
M3 - Article
C2 - 646536
AN - SCOPUS:0018122684
SN - 0003-9926
VL - 138
SP - 735
EP - 738
JO - Archives of internal medicine
JF - Archives of internal medicine
IS - 5
ER -