Coadministration of oral levofloxacin with agents that impair absorption: Impact on antibiotic resistance

Keira A. Cohen, Ebbing Lautenbach, Mark G. Weiner, Marie Synnestvedt, Leanne B. Gasink

Research output: Contribution to journalArticlepeer-review

Abstract

Coadministration of oral divalent or trivalent cation-containing compounds with oral fluoroquinolones may impair fluoroquinolone absorption. Among 3,134 patients who received a course of oral levofloxacin, coadministration was significantly associated with subsequent identification of a levofloxacin-resistant isolate. Strategies to curb the emergence of fluoroquinolone resistance should include avoiding the coadministration of divalent or trivalent cation-containing compounds and fluoroquinolone.

Original languageEnglish (US)
Pages (from-to)975-977
Number of pages3
JournalInfection control and hospital epidemiology
Volume29
Issue number10
DOIs
StatePublished - Oct 2008
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

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