Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses

Shengdian Wang, Lieping Chen

Research output: Contribution to journalArticle

Abstract

Co-signaling molecules in the B7-CD28 family have been intensively studied over the past decade and have brought much excitement to the field of immune regulation. The discovery of new functions for the classical pathways CD80/CD86/CD28/CTLA-4 and the identification of novel pathways of the family, including B7-H1/B7-DC/PD-1, B7-H2/ICOS, B7-H3, B7-H4 and BTLA, are greatly broadening our understanding of the control of T cell-mediated immune responses and tolerance.

Original languageEnglish (US)
Pages (from-to)759-766
Number of pages8
JournalMicrobes and Infection
Volume6
Issue number8
DOIs
StatePublished - Jul 2004
Externally publishedYes

Keywords

  • B7
  • CD28
  • Costimulation
  • T cell activation

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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