Abstract
Co-signaling molecules in the B7-CD28 family have been intensively studied over the past decade and have brought much excitement to the field of immune regulation. The discovery of new functions for the classical pathways CD80/CD86/CD28/CTLA-4 and the identification of novel pathways of the family, including B7-H1/B7-DC/PD-1, B7-H2/ICOS, B7-H3, B7-H4 and BTLA, are greatly broadening our understanding of the control of T cell-mediated immune responses and tolerance.
Original language | English (US) |
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Pages (from-to) | 759-766 |
Number of pages | 8 |
Journal | Microbes and Infection |
Volume | 6 |
Issue number | 8 |
DOIs | |
State | Published - Jul 2004 |
Externally published | Yes |
Keywords
- B7
- CD28
- Costimulation
- T cell activation
ASJC Scopus subject areas
- Microbiology
- Infectious Diseases