CO-Opting the Host HO-1 Pathway in Tuberculosis and Malaria

Photini Sinnis, Joel D. Ernst

Research output: Contribution to journalShort surveypeer-review

Abstract

Infection with Mycobacterium tuberculosis and Plasmodium species results in upregulation of the host heme oxygenase-1 pathway. In tuberculosis infection, this leads to upregulation of the bacterial "dormancy regulon," whereas in malaria, it enhances the efficiency with which sporozoites develop into exoerythrocytic stages. Here we discuss these findings as well as some of the interesting questions they raise.

Original languageEnglish (US)
Pages (from-to)277-279
Number of pages3
JournalCell Host and Microbe
Volume3
Issue number5
DOIs
StatePublished - May 15 2008
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

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