TY - JOUR
T1 - Co-occurrence and Severity of Neurodevelopmental Burden (Cognitive Impairment, Cerebral Palsy, Autism Spectrum Disorder, and Epilepsy) at Age Ten Years in Children Born Extremely Preterm
AU - ELGAN Study Investigators
AU - Hirschberger, Rachel G.
AU - Kuban, Karl C.K.
AU - O'Shea, Thomas M.
AU - Joseph, Robert M.
AU - Heeren, Tim
AU - Douglass, Laurie M.
AU - Stafstrom, Carl E.
AU - Jara, Hernan
AU - Frazier, Jean A.
AU - Hirtz, Deborah
AU - Rollins, Julie V.
AU - Paneth, Nigel
AU - Ware, Janice
AU - Coster, Taryn
AU - Hanson, Brandi
AU - Wilson, Rachel
AU - McGhee, Kirsten
AU - Lee, Patricia
AU - Asgarian, Aimee
AU - Sadhwani, Anjali
AU - Perrin, Ellen
AU - Neger, Emily
AU - Mattern, Kathryn
AU - Walkowiak, Jenifer
AU - Barron, Susan
AU - Shah, Bhavesh
AU - Singh, Rachana
AU - Smith, Anne
AU - Klein, Deborah
AU - McQuiston, Susan
AU - Venuti, Lauren
AU - Powers, Beth
AU - Foley, Ann
AU - Dessureau, Brian
AU - Wood, Molly
AU - Damon-Minow, Jill
AU - Ehrenkranz, Richard
AU - Benjamin, Jennifer
AU - Romano, Elaine
AU - Tsatsanis, Kathy
AU - Chawarska, Katarzyna
AU - Kim, Sophy
AU - Dieterich, Susan
AU - Bearrs, Karen
AU - Peters, Nancy
AU - Brown, Patricia
AU - Ansusinha, Emily
AU - Waldrep, Ellen
AU - Friedman, Jackie
AU - Hounshell, Gail
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/2
Y1 - 2018/2
N2 - Background: This study aims to determine the prevalence of neurodevelopmental impairments at age ten years among children born extremely preterm (less than 28 weeks gestational age) and to offer a framework for categorizing neurological limitations. Methods: A multicenter, prospective cohort follow-up study recruited 889 ten-year-old children born from 2002 to 2004. We assessed prevalence of cognitive impairment, measured by intelligent quotient and tests of executive function, cerebral palsy (CP), autism spectrum disorder (ASD), and epilepsy singly and in combination. The three levels of impairment severity were: category I—no major neurodevelopmental impairment; category II—normal cognitive ability with CP, ASD, and/or epilepsy; and category III—children with cognitive impairment. Results: A total 214 of 873 children (25%) had cognitive impairment, 93 of 849 children (11%) had CP, 61 of 857 children (7%) had ASD, and 66 of 888 children (7%) had epilepsy. Further, 19% of all children had one diagnosis, 10% had two diagnoses, and 3% had three diagnoses. Decreasing gestational age was associated with increasing number of impairments (P < 0.001). Half the children with cognitive impairment and one third of children with CP, ASD, or epilepsy had a single impairment. Six hundred one (68% [95% CI, 64.5%-70.7%]) children were in category I, 74 (8% [95% CI, 6.6%-10.3%]) were in category II, and 214 (24% [95% CI 21.7%-27.4%]) were in category III. Conclusions: Three quarters of children had normal intellect at age ten years; nearly 70% were free of neurodevelopmental impairment. Forty percent of children with impairments had multiple diagnoses.
AB - Background: This study aims to determine the prevalence of neurodevelopmental impairments at age ten years among children born extremely preterm (less than 28 weeks gestational age) and to offer a framework for categorizing neurological limitations. Methods: A multicenter, prospective cohort follow-up study recruited 889 ten-year-old children born from 2002 to 2004. We assessed prevalence of cognitive impairment, measured by intelligent quotient and tests of executive function, cerebral palsy (CP), autism spectrum disorder (ASD), and epilepsy singly and in combination. The three levels of impairment severity were: category I—no major neurodevelopmental impairment; category II—normal cognitive ability with CP, ASD, and/or epilepsy; and category III—children with cognitive impairment. Results: A total 214 of 873 children (25%) had cognitive impairment, 93 of 849 children (11%) had CP, 61 of 857 children (7%) had ASD, and 66 of 888 children (7%) had epilepsy. Further, 19% of all children had one diagnosis, 10% had two diagnoses, and 3% had three diagnoses. Decreasing gestational age was associated with increasing number of impairments (P < 0.001). Half the children with cognitive impairment and one third of children with CP, ASD, or epilepsy had a single impairment. Six hundred one (68% [95% CI, 64.5%-70.7%]) children were in category I, 74 (8% [95% CI, 6.6%-10.3%]) were in category II, and 214 (24% [95% CI 21.7%-27.4%]) were in category III. Conclusions: Three quarters of children had normal intellect at age ten years; nearly 70% were free of neurodevelopmental impairment. Forty percent of children with impairments had multiple diagnoses.
KW - extremely preterm
KW - follow-up
KW - multiple disabilities
KW - neurological
UR - http://www.scopus.com/inward/record.url?scp=85039941779&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85039941779&partnerID=8YFLogxK
U2 - 10.1016/j.pediatrneurol.2017.11.002
DO - 10.1016/j.pediatrneurol.2017.11.002
M3 - Article
C2 - 29310907
AN - SCOPUS:85039941779
SN - 0887-8994
VL - 79
SP - 45
EP - 52
JO - Pediatric Neurology
JF - Pediatric Neurology
ER -