Co-Localization of Macrophage Inhibitory Factor and Nix in Skeletal Muscle of the Aged Male Interleukin 10 Null Mouse

P. Abadir, F. Ko, Ruth Marx-Rattner, L. Powell, E. Kieserman, H. Yang, J. Walston

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic inflammation is associated with muscle weakness and frailty in older adults. The antagonistic cross-talk between macrophage migration inhibitory factor (Mif), an anti-apoptotic cytokine and NIP3-like protein X (Nix), a pro-apoptotic mitochondrial protein, may play a role in mitochondrial free radical homeostasis and inflammatory myopathies. We examined Nix-Mif interaction in inflammation and aging using young and old, IL-10tm/tm (a rodent model of chronic inflammation) and C57BL/6 mice. In this study, we observed that Nix and Mif were co-localized in skeletal muscles of aged and inflamed mice. We show an inflammation- and age-related association between Nix and Mif gene expression, with the strongest positive correlation observed in old IL-10tm/tm skeletal muscles. The IL-10tm/tm skeletal muscles also had the highest levels of oxidative stress damage. These observations suggest that Nix-Mif cross-talk may play a role in the interface between chronic inflammation and oxidative stress in aging skeletal muscles.

Original languageEnglish (US)
Pages (from-to)118-121
Number of pages4
JournalThe Journal of frailty & aging
Volume6
Issue number3
DOIs
StatePublished - 2017

Keywords

  • IL-10
  • Mif
  • Nix
  • oxidative stress

ASJC Scopus subject areas

  • Medicine(all)

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