TY - JOUR
T1 - Co-localization of GABA and neuropeptides in neocortical neurons
AU - Jones, Edward G.
AU - Hendry, Stewart H.C.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1986
Y1 - 1986
N2 - A number of well known brain-gut peptides are found in the cerebral cortex. Those with the highest concentrations are almost always co-localized with both conventional transmitters (particularly GABA) and/or with other peptides within limited populations of cortical intrinsic neurons. The neurons containing both GABA and a peptide have similar morphology but particular sub-groups can be identified in terms of the peptides they contain and their synaptic targets. Levels of one cortical peptide, somatostatin, decline in Alzheimer's disease without a concomitant decline in GABA, with which it is co-localized. This and certain other puzzling features of peptide action and peptidergic cell morphology suggest that some may mediate trophic, and other effects on cortical neurons.
AB - A number of well known brain-gut peptides are found in the cerebral cortex. Those with the highest concentrations are almost always co-localized with both conventional transmitters (particularly GABA) and/or with other peptides within limited populations of cortical intrinsic neurons. The neurons containing both GABA and a peptide have similar morphology but particular sub-groups can be identified in terms of the peptides they contain and their synaptic targets. Levels of one cortical peptide, somatostatin, decline in Alzheimer's disease without a concomitant decline in GABA, with which it is co-localized. This and certain other puzzling features of peptide action and peptidergic cell morphology suggest that some may mediate trophic, and other effects on cortical neurons.
UR - http://www.scopus.com/inward/record.url?scp=0022620789&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022620789&partnerID=8YFLogxK
U2 - 10.1016/0166-2236(86)90026-3
DO - 10.1016/0166-2236(86)90026-3
M3 - Review article
AN - SCOPUS:0022620789
SN - 0166-2236
VL - 9
SP - 71
EP - 76
JO - Trends in neurosciences
JF - Trends in neurosciences
IS - C
ER -