Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity

Lieping Chen

Research output: Contribution to journalArticlepeer-review

955 Scopus citations


Co-signalling molecules are cell-surface glycoproteins that can direct, modulate and fine-tune T-cell receptor (TCR) signals. On the basis of their functional outcome, co-signalling molecules can be divided into co-stimulators and co-inhibitors, which promote or suppress T-cell activation, respectively. By expression at the appropriate time and location, co-signalling molecules positively and negatively control the priming, growth, differentiation and functional maturation of a T-cell response. We are now beginning to understand the power of co-inhibitors in the context of lymphocyte homeostasis and the pathogenesis of human diseases. In this article, I focus on several newly described co-inhibitory pathways in the B7-CD28 family.

Original languageEnglish (US)
Pages (from-to)336-347
Number of pages12
JournalNature Reviews Immunology
Issue number5
StatePublished - May 2004

ASJC Scopus subject areas

  • Immunology


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