TY - JOUR
T1 - Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity
AU - Chen, Lieping
PY - 2004/5
Y1 - 2004/5
N2 - Co-signalling molecules are cell-surface glycoproteins that can direct, modulate and fine-tune T-cell receptor (TCR) signals. On the basis of their functional outcome, co-signalling molecules can be divided into co-stimulators and co-inhibitors, which promote or suppress T-cell activation, respectively. By expression at the appropriate time and location, co-signalling molecules positively and negatively control the priming, growth, differentiation and functional maturation of a T-cell response. We are now beginning to understand the power of co-inhibitors in the context of lymphocyte homeostasis and the pathogenesis of human diseases. In this article, I focus on several newly described co-inhibitory pathways in the B7-CD28 family.
AB - Co-signalling molecules are cell-surface glycoproteins that can direct, modulate and fine-tune T-cell receptor (TCR) signals. On the basis of their functional outcome, co-signalling molecules can be divided into co-stimulators and co-inhibitors, which promote or suppress T-cell activation, respectively. By expression at the appropriate time and location, co-signalling molecules positively and negatively control the priming, growth, differentiation and functional maturation of a T-cell response. We are now beginning to understand the power of co-inhibitors in the context of lymphocyte homeostasis and the pathogenesis of human diseases. In this article, I focus on several newly described co-inhibitory pathways in the B7-CD28 family.
UR - http://www.scopus.com/inward/record.url?scp=2442585121&partnerID=8YFLogxK
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M3 - Article
C2 - 15122199
AN - SCOPUS:2442585121
SN - 1474-1733
VL - 4
SP - 336
EP - 347
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 5
ER -