TY - JOUR
T1 - CNS vasculitis in a patient with MS on daclizumab monotherapy
AU - Ohayon, Joan
AU - Oh, Unsong
AU - Richert, Nancy
AU - Martin, Jayne
AU - Vortmeyer, Alexander
AU - McFarland, Henry
AU - Bielekova, Bibiana
PY - 2013/1/29
Y1 - 2013/1/29
N2 - Objective: To report the development of CNS vasculitis in a patientwithmultiple sclerosis (MS) treated with daclizumab. Methods: This report includes clinical, MRI, immunologic, and pathology data and CSF analysis. Results: After completing a phase II daclizumab monotherapy study with an optimal response as evidenced by significant decrease in MRI disease activity and stable clinical examinations, the patient elected to continue daclizumab therapy outside of NIH study. Daclizumab was discontinued after 21 doses due to the onset of new clinical symptoms and evidence of a vascular pattern of contrast enhancement on brain and spine MRI. Because of continued clinical deterioration, stereotactic brain biopsy was performed, showing small-vessel CNS vasculitis. Treatment was initiated with IV methylprednisolone followed by a regimen of cyclophosphamide. Immunologic studies suggest that unexpected lack of expansion of CD56bright NK cells and predictable decline in FoxP31 T-regs combined with a transient interruption in daclizumab dosing may have contributed to this serious side effect. Conclusions: Only safety data from larger phase III studies and potentially postmarketing experience will define the exact risk of daclizumab-induced immunopathologies. Nevertheless, our case provides plausible hypothesis and potential biomarker that may be used to screen susceptible patients and implement preventive safety measures during potentially vulnerable periods.
AB - Objective: To report the development of CNS vasculitis in a patientwithmultiple sclerosis (MS) treated with daclizumab. Methods: This report includes clinical, MRI, immunologic, and pathology data and CSF analysis. Results: After completing a phase II daclizumab monotherapy study with an optimal response as evidenced by significant decrease in MRI disease activity and stable clinical examinations, the patient elected to continue daclizumab therapy outside of NIH study. Daclizumab was discontinued after 21 doses due to the onset of new clinical symptoms and evidence of a vascular pattern of contrast enhancement on brain and spine MRI. Because of continued clinical deterioration, stereotactic brain biopsy was performed, showing small-vessel CNS vasculitis. Treatment was initiated with IV methylprednisolone followed by a regimen of cyclophosphamide. Immunologic studies suggest that unexpected lack of expansion of CD56bright NK cells and predictable decline in FoxP31 T-regs combined with a transient interruption in daclizumab dosing may have contributed to this serious side effect. Conclusions: Only safety data from larger phase III studies and potentially postmarketing experience will define the exact risk of daclizumab-induced immunopathologies. Nevertheless, our case provides plausible hypothesis and potential biomarker that may be used to screen susceptible patients and implement preventive safety measures during potentially vulnerable periods.
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U2 - 10.1212/WNL.0b013e31827f0f42
DO - 10.1212/WNL.0b013e31827f0f42
M3 - Article
C2 - 23303850
AN - SCOPUS:84873661188
SN - 0028-3878
VL - 80
SP - 453
EP - 457
JO - Neurology
JF - Neurology
IS - 5
ER -