CMV infection and frailty: Immunologic consequences and disease pathogenesis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Frailty is a common geriatric syndrome that has been variously characterized as a wasting state of decreased physiologic reserve, loss of physiologic complexity, and accumulation of deficits [11, 58, 83], and is an independent risk factor for poor outcomes in older adults [7, 30, 113]. A physiologic phenomenon that has been consistently observed in frail older individuals is a generalized inflammatory state, beyond age-related changes [26, 56, 87, 106]. Frail older adults have higher levels of systemic inflammatory markers, including interleukin-6 and C-reactive protein, than older adults who are not frail, even when chronic diseases are excluded [106]. The chronic activation of inflammatory pathways is known to influence skeletal muscle mass decline, the anemia of chronic disease, hypothalamic-pituitary-adrenal axis (HPA axis) activity, cognition, and a number of chronic disease states, and likely plays an important role in the pathogenesis of frailty through its effects on these multiple physiologic systems [28].

Original languageEnglish (US)
Title of host publicationHandbook on Immunosenescence
Subtitle of host publicationBasic Understanding and Clinical Applications
PublisherSpringer Netherlands
Pages1305-1326
Number of pages22
Volume9781402090639
ISBN (Electronic)9781402090639
ISBN (Print)9781402090622
DOIs
StatePublished - 2009

Keywords

  • Cytomegalovirus
  • Frailty
  • Immunosenescence
  • Inflammation
  • T-cells

ASJC Scopus subject areas

  • Medicine(all)

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