CMR imaging with rapid visual T1 assessment predicts mortality in patients suspected of cardiac amyloidosis

James A. White, Han W. Kim, Dipan Shah, Nowell Fine, Ki Young Kim, David C. Wendell, Wael Al-Jaroudi, Michele Parker, Manesh Patel, Femida Gwadry-Sridhar, Robert M. Judd, Raymond J. Kim

Research output: Contribution to journalArticle

Abstract

Objectives This study tested the diagnostic and prognostic utility of a rapid, visual T1 assessment method for identification of cardiac amyloidosis (CA) in a "real-life" referral population undergoing cardiac magnetic resonance for suspected CA. Background In patients with confirmed CA, delayed-enhancement cardiac magnetic resonance (DE-CMR) frequently shows a diffuse, global hyperenhancement (HE) pattern. However, imaging is often technically challenging, and the prognostic significance of diffuse HE is unclear. Methods Ninety consecutive patients referred for suspected CA and 64 hypertensive patients with left ventricular hypertrophy (LVH) were prospectively enrolled and underwent a modified DE-CMR protocol. After gadolinium administration a method for rapid, visual T1 assessment was used to identify the presence of diffuse HE during the scan, allowing immediate optimization of settings for the conventional DE-CMR that followed. The primary endpoint was all-cause mortality. Results Among patients with suspected CA, 66% (59 of 90) demonstrated HE, with 81% (48 of 59) of these meeting pre-specified visual T1 assessment criteria for diffuse HE. Among hypertensive LVH patients, 6% (4 of 64) had HE, with none having diffuse HE. During 29 months of follow-up (interquartile range: 12 to 44 months), there were 50 (56%) deaths in patients with suspected CA and 4 (6%) in patients with hypertensive LVH. Multivariable analysis demonstrated that the presence of diffuse HE was the most important predictor of death in the group with suspected CA (hazard ratio: 5.5, 95% confidence interval: 2.7 to 11.0; p < 0.0001) and in the population as a whole (hazard ratio: 6.0, 95% confidence interval 3.0 to 12.1; p < 0.0001). Among 25 patients with myocardial histology obtained during follow-up, the sensitivity, specificity, and accuracy of diffuse HE in the diagnosis of CA were 93%, 70%, and 84%, respectively. Conclusions Among patients suspected of CA, the presence of diffuse HE by visual T1 assessment accurately identifies patients with histologically-proven CA and is a strong predictor of mortality.

Original languageEnglish (US)
Pages (from-to)143-156
Number of pages14
JournalJACC: Cardiovascular Imaging
Volume7
Issue number2
DOIs
StatePublished - Feb 1 2014

Keywords

  • amyloid
  • delayed enhancement
  • magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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    White, J. A., Kim, H. W., Shah, D., Fine, N., Kim, K. Y., Wendell, D. C., Al-Jaroudi, W., Parker, M., Patel, M., Gwadry-Sridhar, F., Judd, R. M., & Kim, R. J. (2014). CMR imaging with rapid visual T1 assessment predicts mortality in patients suspected of cardiac amyloidosis. JACC: Cardiovascular Imaging, 7(2), 143-156. https://doi.org/10.1016/j.jcmg.2013.09.019