Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases

Kevin G. Becker, Richard M. Simon, Joan E. Bailey-Wilson, Boris Freidlin, William E. Biddison, Henry F. Mcfarland, Jeffrey M. Trent

Research output: Contribution to journalArticle

Abstract

Human autoimmune diseases are thought to develop through a complex combination of genetic and environmental factors. Genome-wide linkage searches of autoimmune and inflammatory/immune disorders have identified a large number of non-major histocompatibility complex loci that collectively contribute to disease susceptibility. A comparison was made of the linkage results from 23 published autoimmune or immune-mediated disease genome-wide scans. Human diseases included multiple sclerosis, Crohn's disease, familial psoriasis, asthma, and type-I diabetes (IDDM). Experimental animal disease studies included murine experimental autoimmune encephalomyelitis, rat inflammatory arthritis, rat and murine IDDM, histamine sensitization, immunity to exogenous antigens, and murine lupus (systemic lupus erythematosus; SLE). A majority (≃65%) of the human positive linkages map nonrandomly into 18 distinct clusters. Overlapping of susceptibility loci occurs between different human immune diseases and by comparing conserved regions with experimental autoimmune/immune disease models. This nonrandom clustering supports a hypothesis that, in some cases, clinically distinct autoimmune diseases may be controlled by a common set of susceptibility genes.

Original languageEnglish (US)
Pages (from-to)9979-9984
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume95
Issue number17
DOIs
StatePublished - Aug 18 1998
Externally publishedYes

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Immune System Diseases
Major Histocompatibility Complex
Autoimmune Diseases
Cluster Analysis
Type 1 Diabetes Mellitus
Genome
Animal Diseases
Autoimmune Experimental Encephalomyelitis
Disease Susceptibility
Psoriasis
Crohn Disease
Systemic Lupus Erythematosus
Histamine
Multiple Sclerosis
Arthritis
Immunity
Asthma
Antigens
Genes

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases. / Becker, Kevin G.; Simon, Richard M.; Bailey-Wilson, Joan E.; Freidlin, Boris; Biddison, William E.; Mcfarland, Henry F.; Trent, Jeffrey M.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, No. 17, 18.08.1998, p. 9979-9984.

Research output: Contribution to journalArticle

Becker, Kevin G. ; Simon, Richard M. ; Bailey-Wilson, Joan E. ; Freidlin, Boris ; Biddison, William E. ; Mcfarland, Henry F. ; Trent, Jeffrey M. / Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases. In: Proceedings of the National Academy of Sciences of the United States of America. 1998 ; Vol. 95, No. 17. pp. 9979-9984.
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