TY - JOUR
T1 - Clustering of human papillomavirus (HPV) types in the male genital tract
T2 - The HPV in men (HIM) study
AU - Vaccarella, Salvatore
AU - Plummer, Martyn
AU - Franceschi, Silvia
AU - Gravitt, Patti
AU - Papenfuss, Mary
AU - Smith, Danelle
AU - Villa, Luisa
AU - Ponce, Eduardo Lazcano
AU - Giuliano, Anna R.
N1 - Funding Information:
Financial support. The HPV in men (HIM) study is funded by the National Institutes of Health (R01 CA 098803).
PY - 2011/11/15
Y1 - 2011/11/15
N2 - Objective.To evaluate clustering patterns of prevalent infection with multiple human papillomavirus (HPV) types in 3677 men from the HPV in Men (HIM) study.Methods.HPV testing was performed in samples combined from the glans penis/coronal sulcus, the shaft, and the scrotum by Linear Array methodology. Linear Array uses a mixed probe to assess HPV52 positivity, which limits the assay's ability to determine HPV52 status in the presence of HPV33, 35, or 58. Logistic regression was used to model type-specific HPV positivity, adjusted for age, study area, lifetime number of sexual partners, and specific HPV type prevalence. Participant-level random effects were added to represent unobservable risk factors common to all HPV types.Results.The observed-to-expected ratio for infections with ≥ 3 types was 1.09 (95% credible interval, 1.04-1.14). For the majority of 2-type combinations, no evidence was found of a significant departure of the observed from the expected number. An apparent clustering of HPV52 with HPV35 or 58 was observed, because of limitation in the ability of Linear Array to define HPV52 positivity.Conclusions.Our study showed that, despite obvious anatomical differences, HPV coinfections do seem to occur at random in the male external genitalia as in the female cervix.
AB - Objective.To evaluate clustering patterns of prevalent infection with multiple human papillomavirus (HPV) types in 3677 men from the HPV in Men (HIM) study.Methods.HPV testing was performed in samples combined from the glans penis/coronal sulcus, the shaft, and the scrotum by Linear Array methodology. Linear Array uses a mixed probe to assess HPV52 positivity, which limits the assay's ability to determine HPV52 status in the presence of HPV33, 35, or 58. Logistic regression was used to model type-specific HPV positivity, adjusted for age, study area, lifetime number of sexual partners, and specific HPV type prevalence. Participant-level random effects were added to represent unobservable risk factors common to all HPV types.Results.The observed-to-expected ratio for infections with ≥ 3 types was 1.09 (95% credible interval, 1.04-1.14). For the majority of 2-type combinations, no evidence was found of a significant departure of the observed from the expected number. An apparent clustering of HPV52 with HPV35 or 58 was observed, because of limitation in the ability of Linear Array to define HPV52 positivity.Conclusions.Our study showed that, despite obvious anatomical differences, HPV coinfections do seem to occur at random in the male external genitalia as in the female cervix.
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U2 - 10.1093/infdis/jir595
DO - 10.1093/infdis/jir595
M3 - Article
C2 - 21908729
AN - SCOPUS:80054759100
SN - 0022-1899
VL - 204
SP - 1500
EP - 1504
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 10
ER -