Cluster randomised trials, second edition

Richard J. Hayes, Lawrence Hale Moulton

Research output: Book/ReportBook

Abstract

Cluster Randomised Trials, Second Edition discusses the design, conduct, and analysis of trials that randomise groups of individuals to different treatments. It explores the advantages of cluster randomisation, with special attention given to evaluating the effects of interventions against infectious diseases. Avoiding unnecessary mathematical detail, the book covers basic concepts underlying the use of cluster randomisation, such as direct, indirect, and total effects. In the time since the publication of the first edition, the use of cluster randomised trials (CRTs) has increased substantially, which is reflected in the updates to this edition. There are greatly expanded sections on randomisation, sample size estimation, and alternative designs, including new material on stepped wedge designs. There is a new section on handling ordinal outcome data, and an appendix with descriptions and/or generating code of the example data sets. Although the book mainly focuses on medical and public health applications, it shows that the rigorous evidence of intervention effects provided by CRTs has the potential to inform public policy in a wide range of other areas. The book encourages readers to apply the methods to their own trials, reproduce the analyses presented, and explore alternative approaches.

Original languageEnglish (US)
PublisherCRC Press
Number of pages398
ISBN (Electronic)9781498728232
ISBN (Print)9781498728225
DOIs
StatePublished - Jan 1 2017

Fingerprint

Randomized Trial
Random Allocation
Randomisation
Public Policy
Sample Size
Communicable Diseases
Publications
Public Health
Alternatives
Infectious Diseases
Wedge
Update
Cover
Range of data
Design

ASJC Scopus subject areas

  • Mathematics(all)
  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Cluster randomised trials, second edition. / Hayes, Richard J.; Moulton, Lawrence Hale.

CRC Press, 2017. 398 p.

Research output: Book/ReportBook

Hayes, Richard J. ; Moulton, Lawrence Hale. / Cluster randomised trials, second edition. CRC Press, 2017. 398 p.
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