Cluster of Urrets-Zavalia syndrome: A sequel of toxic anterior segment syndrome

Noor Bakht Nizamani, Imran Ahmed Bhutto, Khalid Iqbal Talpur

Research output: Contribution to journalArticle

Abstract

Purpose: To report the largest cluster of Urrets-Zavalia Syndrome (UZS), which occurred as a sequel of toxic anterior segment syndrome (TASS) after uneventful cataract surgery, and to evaluate the possible causes and risk factors to prevent additional cases. Setting: Department of Ophthalmology, Liaquat University of Medical & Health Sciences, Hyderabad, Pakistan. Design: Prospective Case Series. Methods: 15 consecutive TASS cases following uneventful cataract surgery were evaluated for potential causes and risk factors. Main outcome measures included visual acuity, anterior segment reaction, corneal oedema, intraocular pressure, pupillary reaction and response to topical and/or systemic steroid therapy at first day, first week and first month postoperatively. Results: The TASS incidence in this study was 0.08%. All cases presented with corneal oedema, anterior chamber reaction and fixed dilated pupils on first postoperative day. One month postoperatively, the anterior segment inflammation improved considerably in all patients. There was a statistically significant difference between the mean Best-corrected visual acuity (BCVA) at first postoperative day (2.32±0.93 LogMAR) and mean BCVA at 1 month (0.49±0.12 LogMAR) (p=0.0001). The rate of UZS in this study was 93%. Ringer lactate solution was found to be the offending agent of TASS, and replacing it brought a halt to this cluster. Conclusions: Timely diagnosis, steroid therapy and close monitoring are the main keys for properly managing TASS. To our knowledge, we report, for the first time, the largest cluster of UZS occurring as a sequel of TASS.

Original languageEnglish (US)
Pages (from-to)976-979
Number of pages4
JournalBritish Journal of Ophthalmology
Volume97
Issue number8
DOIs
StatePublished - Aug 2013

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Poisons
Visual Acuity
Corneal Edema
Cataract
Steroids
Pupil Disorders
Pakistan
Anterior Chamber
Ophthalmology
Intraocular Pressure
Cohort Studies
Outcome Assessment (Health Care)
Inflammation
Health
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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Cluster of Urrets-Zavalia syndrome : A sequel of toxic anterior segment syndrome. / Nizamani, Noor Bakht; Bhutto, Imran Ahmed; Talpur, Khalid Iqbal.

In: British Journal of Ophthalmology, Vol. 97, No. 8, 08.2013, p. 976-979.

Research output: Contribution to journalArticle

Nizamani, Noor Bakht ; Bhutto, Imran Ahmed ; Talpur, Khalid Iqbal. / Cluster of Urrets-Zavalia syndrome : A sequel of toxic anterior segment syndrome. In: British Journal of Ophthalmology. 2013 ; Vol. 97, No. 8. pp. 976-979.
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