Clozapine response and the 5HT(2C) Cys23Ser polymorphism

Anil K. Malhotra, David Goldman, Norio Ozaki, Walter Rooney, Allan Clifton, Robert W. Buchanan, Alan Breier, David Pickar

Research output: Contribution to journalArticle


The presence of the 5HT(2C) receptor allele, Ser23, has recently been reported to predict favorable response to the antipsychotic drug, clozapine. This finding is of interest as Ser23, compared with the more abundant Cys23, alters pharmacological characteristics of the receptor and therefore may provide insights into the mechanism of action of antipsychotic drugs. We determined 5HT(2C) receptor genotype at the Cys23Ser locus in 66 subjects participating in double-blind studies of clozapine. There was no relationship between Ser23 and clozapine response (p = 0.30, Fisher's exact) nor was there any effect of Ser23 upon absolute levels of psychiatric symptoms after 10 weeks of clozapine treatment (t = -0.57, p = 0.57). These data suggest that this 5HT(2C) receptor polymorphism is not associated with clozapine response.

Original languageEnglish (US)
Pages (from-to)2100-2102
Number of pages3
Issue number13
StatePublished - 1996
Externally publishedYes


  • 5HT(2C) receptor
  • Allele
  • Amino acid substitution
  • Association study
  • Clozapine
  • Genotype
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Malhotra, A. K., Goldman, D., Ozaki, N., Rooney, W., Clifton, A., Buchanan, R. W., Breier, A., & Pickar, D. (1996). Clozapine response and the 5HT(2C) Cys23Ser polymorphism. NeuroReport, 7(13), 2100-2102.