Clozapine for treatment-resistant agitation in dementia

Hochang B. Lee, Jennifer A. Hanner, Jessica L. Yokley, Brian Appleby, Lisa Hurowitz, Constantine G. Lyketsos

Research output: Contribution to journalArticlepeer-review


Few studies have examined the potential role of clozapine in treatment of agitation in dementia patients who have previously failed to respond to standard pharmacotherapy. We conducted a systematic chart review of all elderly patients admitted to our inpatient unit between 2001 and 2004. Of them, 16 dementia patients were treated with clozapine for treatment-resistant agitation, and their charts were blindly rated by 3 clinicians on the Clinical Global Impression (CGI) Scale, Brief Agitation Rating Scale (BARS), and the Cohen-Mansfield Agitation Inventory-Short Form (CMAI-SF). Overall, clozapine therapy seemed beneficial in treatment-resistant agitation in dementia patients.

Original languageEnglish (US)
Pages (from-to)178-182
Number of pages5
JournalJournal of Geriatric Psychiatry and Neurology
Issue number3
StatePublished - Sep 2007


  • Agitation
  • Clozapine
  • Dementia
  • Treatment

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


Dive into the research topics of 'Clozapine for treatment-resistant agitation in dementia'. Together they form a unique fingerprint.

Cite this