Closure of long surgical incisions with a new formulation of 2-octylcyanoacrylate tissue adhesive versus commercially available methods

Phillip N.V. Blondeel, John W. Murphy, Denis Debrosse, James C. Nix, Larry E. Puls, Nicholas Theodore, Paul Coulthard

Research output: Contribution to journalArticle

Abstract

Background Topical 2-octylcyanoacrylate tissue adhesive is an alternative to traditional devices for closing short surgical incisions. Methods An open-label, randomized study compared a new high-viscosity formulation of 2-octylcyanoacrylate with commercially available devices, including low-viscosity 2-octylcyanoacrylate, for epidermal closure of incisions ≥4 cm requiring subcutaneous and/or deep-dermal suturing. Results Of patients with 1 to 3 wounds, 106 were treated with high-viscosity 2-octylcyanoacrylate and 103 with commercially available devices. The day-10 rates of healing by wound were 96% and 97% for study versus control treatment and 97% and 95% for new and old 2-octylcyanoacrylate formulations versus other controls, respectively. Day-10 infection rates by wound were 4 of 145 versus 7 of 131 for study versus control treatment and 6 of 207 and 5 of 69 for new and old 2-octylcyanoacrylate versus other controls, respectively. Conclusions The new tissue adhesive formulation provides epidermal wound closure equivalent to commercially available devices with a trend to decreased incidence of wound infection.

Original languageEnglish (US)
Pages (from-to)307-313
Number of pages7
JournalAmerican journal of surgery
Volume188
Issue number3
DOIs
StatePublished - Sep 2004

Keywords

  • Cyanoacrylates
  • Medical devices
  • Surgery
  • Tissue adhesives
  • Wound healing
  • Wound infection

ASJC Scopus subject areas

  • Surgery

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