Clostridium difficile infection: Pathophysiology and diagnosis

Research output: Contribution to journalArticle

Abstract

Clostridium difficile is a relatively common enteric pathogen encountered most frequently in association with antibiotic use and as a nosocomial pathogen. Four factors dictate clinical expression: (1) acquisition of the organism from environmental sources or previous colonization; (2) distortion of the competing colonic flora by antibiotics;(3) toxin production; and (4) age-related susceptibility. Characteristics of clinical features include inflammatory diarrhea (cramps, fecal leukocytes, systemic response), endoscopic evidence of colitis or pseudomembranous colitis, and protein-losing enteropathy. The usual diagnostic tests are designed to detect toxin B with a tissue culture assay or toxin A with an enzyme immunoassay.

Original languageEnglish (US)
Pages (from-to)12-21
Number of pages10
JournalSeminars in Gastrointestinal Disease
Volume8
Issue number1
StatePublished - 1997

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Clostridium Infections
Clostridium difficile
Protein-Losing Enteropathies
Anti-Bacterial Agents
Pseudomembranous Enterocolitis
Muscle Cramp
Colitis
Immunoenzyme Techniques
Routine Diagnostic Tests
Diarrhea
Leukocytes

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Clostridium difficile infection : Pathophysiology and diagnosis. / Bartlett, John.

In: Seminars in Gastrointestinal Disease, Vol. 8, No. 1, 1997, p. 12-21.

Research output: Contribution to journalArticle

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