Clostridium difficile in antibiotic associated pediatric diarrhea

P. Dutta, S. K. Niyogi, U. Mitra, R. Rasaily, M. K. Bhattacharya, S. Chakraborty, A. Mitra

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


A case control study was carried out at the medical wards of Dr. B.C. Roy Memorial Hospital for Children, Calcutta, between January and September 1989. One hundred eleven hospitalized children up to the age of 5 years, receiving antibiotics for different medical problems, developed antibiotic associated diarrhea. Isolation of Clostridium difficile as sole pathogen was very low (3.6%) from these patients. Fecal samples of 111 case matched control children were also screened for C. difficile. Only 2.7% fecal samples of control children were positive for C. difficile. All the strains of C. difficile isolated from antibiotic associated diarrhea cases showed neutralisable cytotoxin in in vitro test. In contrast none of the strains isolated from control children showed cytotoxicity. This study suggests that C. difficile is not an important pathogen related to antibiotic associated diarrhea in children at this hospital.

Original languageEnglish (US)
Pages (from-to)121-126
Number of pages6
JournalIndian pediatrics
Issue number2
StatePublished - 1994
Externally publishedYes


  • Clostridium difficile
  • antibiotic associated
  • diarrhea

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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