Clostridium difficile-associated cecitis in guinea pigs exposed to penicillin.

B. R. Lowe, J. G. Fox, J. G. Bartlett

Research output: Contribution to journalArticlepeer-review


Penicillin treatment resulted in lethal hemorrhagic cecitis in seven of eight guinea pigs. Cecal contents at necropsy from all seven animals contained a cytopathic toxin which was neutralized by Clostridium sordellii and C difficile antitoxins. Bacteriologic cultural examinations of these specimens yielded penicillin-sensitive strains of C difficile which produced a similar or identical cytotoxin in vitro. Stools obtained before penicillin administration and cecal contents from control animals lacked a cytotoxin and cultures failed to yield C difficile. Intracecal injection of cell-free supernatant of C difficile broth cultures reproduced the lesion noted with penicillin treatment. These results implicate C difficile as an agent of penicillin-induced lethal hemorrhagic cecitis in guinea pigs.

Original languageEnglish (US)
Pages (from-to)1277-1279
Number of pages3
JournalAmerican journal of veterinary research
Issue number8
StatePublished - Aug 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • veterinary(all)


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