Abstract
Studies were undertaken to evaluate the effect of Botulinum neurotoxin type-A (BoNTA) preparation on oxytocin-induced contractions of pregnant human myometrium in vitro. Human myometrial tissue was exposed to increasing concentrations (1-50 000 U/mL) of BoNT/A. Isometric contractions were measured using a force displacement transducer. The cumulative effect of BoNT/A on myometrial activity (time to half relaxation [TTR50], frequency, and amplitude) was evaluated. The frequency of myometrial contractions was depressed by 40% from baseline (P <.05) and relaxation time was increased by 30% (P <.05) from baseline within a narrow range of concentrations. There was no significant difference in amplitude. The observed effects were rapidly reversed after complete wash out of the tissue. BoNT/A or its analogues with more specific tissue affinity may be of value as future agents for prevention of unwanted uterine contractile activity associated with preterm labor and fetal surgery.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1001-1004 |
| Number of pages | 4 |
| Journal | Reproductive Sciences |
| Volume | 16 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2009 |
| Externally published | Yes |
Keywords
- Botox
- Clostridium botulinum toxin A
- Preterm labor
- Tocolysis
- Uterine smooth muscle.
ASJC Scopus subject areas
- Obstetrics and Gynecology