Clostridium botulinum toxin a inhibits contractility in pregnant human myometrium in vitro

Irina Burd, Amen Ness, Paul Dimuzio, Gong Yi Ren, Thomas N. Tulenko

Research output: Contribution to journalArticle

Abstract

Studies were undertaken to evaluate the effect of Botulinum neurotoxin type-A (BoNTA) preparation on oxytocin-induced contractions of pregnant human myometrium in vitro. Human myometrial tissue was exposed to increasing concentrations (1-50 000 U/mL) of BoNT/A. Isometric contractions were measured using a force displacement transducer. The cumulative effect of BoNT/A on myometrial activity (time to half relaxation [TTR50], frequency, and amplitude) was evaluated. The frequency of myometrial contractions was depressed by 40% from baseline (P

Original languageEnglish (US)
Pages (from-to)1001-1004
Number of pages4
JournalReproductive Sciences
Volume16
Issue number10
DOIs
StatePublished - Oct 2009
Externally publishedYes

Fingerprint

Botulinum Toxins
Myometrium
Uterine Contraction
Type A Botulinum Toxins
Isometric Contraction
Oxytocin
Transducers
incobotulinumtoxinA
In Vitro Techniques

Keywords

  • Botox
  • Clostridium botulinum toxin A
  • Preterm labor
  • Tocolysis
  • Uterine smooth muscle.

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Clostridium botulinum toxin a inhibits contractility in pregnant human myometrium in vitro. / Burd, Irina; Ness, Amen; Dimuzio, Paul; Ren, Gong Yi; Tulenko, Thomas N.

In: Reproductive Sciences, Vol. 16, No. 10, 10.2009, p. 1001-1004.

Research output: Contribution to journalArticle

Burd, Irina ; Ness, Amen ; Dimuzio, Paul ; Ren, Gong Yi ; Tulenko, Thomas N. / Clostridium botulinum toxin a inhibits contractility in pregnant human myometrium in vitro. In: Reproductive Sciences. 2009 ; Vol. 16, No. 10. pp. 1001-1004.
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