Closing the gap: Unmet needs of individuals with impulsive aggressive behavior observed in children and adolescents

Adelaide S. Robb; Daniel F. Connor; Birgit H. Amann; Benedetto Vitiello; Azmi Nasser; Welton O'Neal; Stefan Schwabe; Gianpiera Ceresoli-Borroni; Jeffrey H. Newcorn; Shawn A. Candler; Jan K. Buitelaar; Robert L. Findling

doi:10.1017/S1092852920001224

Closing the gap: Unmet needs of individuals with impulsive aggressive behavior observed in children and adolescents

Adelaide S. Robb, Daniel F. Connor, Birgit H. Amann, Benedetto Vitiello, Azmi Nasser, Welton O'Neal, Stefan Schwabe, Gianpiera Ceresoli-Borroni, Jeffrey H. Newcorn, Shawn A. Candler, Jan K. Buitelaar, Robert L. Findling

Research output: Contribution to journal › Review article › peer-review

Abstract

Impulsive aggressive (IA, or impulsive aggression) behavior describes an aggregate set of maladaptive, aggressive behaviors occurring across multiple neuropsychiatric disorders. IA is reactive, eruptive, sudden, and unplanned; it provides information about the severity, but not the nature, of its associated primary disorder. IA in children and adolescents is of serious clinical concern for patients, families, and physicians, given the detrimental impact pediatric IA can have on development. Currently, the ability to properly identify, monitor, and treat IA behavior across clinical populations is hindered by two major roadblocks: (1) the lack of an assessment tool designed for and sensitive to the set of behaviors comprising IA, and (2) the absence of a treatment indicated for IA symptomatology. In this review, we discuss the clinical gaps in the approach to monitoring and treating IA behavior, and highlight emerging solutions that may improve clinical outcomes in patients with IA.

Original language	English (US)
Pages (from-to)	448-456
Number of pages	9
Journal	CNS spectrums
Volume	26
Issue number	5
DOIs	https://doi.org/10.1017/S1092852920001224
State	Published - Oct 31 2021
Externally published	Yes

Keywords

Key words ADHD
assessment tool
impulsive aggression
maladaptive aggression
unmet needs

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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10.1017/S1092852920001224

Cite this

Robb, A. S., Connor, D. F., Amann, B. H., Vitiello, B., Nasser, A., O'Neal, W., Schwabe, S., Ceresoli-Borroni, G., Newcorn, J. H., Candler, S. A., Buitelaar, J. K., & Findling, R. L. (2021). Closing the gap: Unmet needs of individuals with impulsive aggressive behavior observed in children and adolescents. CNS spectrums, 26(5), 448-456. https://doi.org/10.1017/S1092852920001224

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abstract = "Impulsive aggressive (IA, or impulsive aggression) behavior describes an aggregate set of maladaptive, aggressive behaviors occurring across multiple neuropsychiatric disorders. IA is reactive, eruptive, sudden, and unplanned; it provides information about the severity, but not the nature, of its associated primary disorder. IA in children and adolescents is of serious clinical concern for patients, families, and physicians, given the detrimental impact pediatric IA can have on development. Currently, the ability to properly identify, monitor, and treat IA behavior across clinical populations is hindered by two major roadblocks: (1) the lack of an assessment tool designed for and sensitive to the set of behaviors comprising IA, and (2) the absence of a treatment indicated for IA symptomatology. In this review, we discuss the clinical gaps in the approach to monitoring and treating IA behavior, and highlight emerging solutions that may improve clinical outcomes in patients with IA.",

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author = "Robb, {Adelaide S.} and Connor, {Daniel F.} and Amann, {Birgit H.} and Benedetto Vitiello and Azmi Nasser and Welton O'Neal and Stefan Schwabe and Gianpiera Ceresoli-Borroni and Newcorn, {Jeffrey H.} and Candler, {Shawn A.} and Buitelaar, {Jan K.} and Findling, {Robert L.}",

note = "Funding Information: Funding. This work was funded by Supernus Pharmaceuticals, Inc., Rockville, MD, USA. Azmi Nasser, Welton O{\textquoteright}Neal, Stefan Schwabe, Gianpiera Ceresoli-Borroni, and Shawn A. Candler, employees of Supernus Pharmaceuticals, Inc., were involved in the design, analysis, and reporting of the literature review. Publisher Copyright: {\textcopyright} ",

year = "2021",

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doi = "10.1017/S1092852920001224",

language = "English (US)",

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AU - Robb, Adelaide S.

AU - Connor, Daniel F.

AU - Amann, Birgit H.

AU - Vitiello, Benedetto

AU - Nasser, Azmi

AU - O'Neal, Welton

AU - Schwabe, Stefan

AU - Ceresoli-Borroni, Gianpiera

AU - Newcorn, Jeffrey H.

AU - Candler, Shawn A.

AU - Buitelaar, Jan K.

AU - Findling, Robert L.

N1 - Funding Information: Funding. This work was funded by Supernus Pharmaceuticals, Inc., Rockville, MD, USA. Azmi Nasser, Welton O’Neal, Stefan Schwabe, Gianpiera Ceresoli-Borroni, and Shawn A. Candler, employees of Supernus Pharmaceuticals, Inc., were involved in the design, analysis, and reporting of the literature review. Publisher Copyright: ©

PY - 2021/10/31

Y1 - 2021/10/31

N2 - Impulsive aggressive (IA, or impulsive aggression) behavior describes an aggregate set of maladaptive, aggressive behaviors occurring across multiple neuropsychiatric disorders. IA is reactive, eruptive, sudden, and unplanned; it provides information about the severity, but not the nature, of its associated primary disorder. IA in children and adolescents is of serious clinical concern for patients, families, and physicians, given the detrimental impact pediatric IA can have on development. Currently, the ability to properly identify, monitor, and treat IA behavior across clinical populations is hindered by two major roadblocks: (1) the lack of an assessment tool designed for and sensitive to the set of behaviors comprising IA, and (2) the absence of a treatment indicated for IA symptomatology. In this review, we discuss the clinical gaps in the approach to monitoring and treating IA behavior, and highlight emerging solutions that may improve clinical outcomes in patients with IA.

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Closing the gap: Unmet needs of individuals with impulsive aggressive behavior observed in children and adolescents

Abstract

Keywords

ASJC Scopus subject areas

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