Closer and closer? Maternal immunization: current promise, future horizons

Cyril Engmann, Jessica A. Fleming, Sadaf Khan, Bruce L. Innis, Jeffrey M. Smith, Joachim Hombach, Ajoke Sobanjo-ter Meulen

Research output: Contribution to journalReview articlepeer-review

Abstract

This state-of-the art manuscript highlights our current understanding of maternal immunization—the practice of vaccinating pregnant women to confer protection on them as well as on their young infants, and thereby reduce vaccine-preventable morbidity and mortality. Advances in our understanding of the immunologic processes that undergird a normal pregnancy, studies from vaccines currently available and recommended for pregnant women, and vaccines for administration in special situations are beginning to build the case for safe scale-up of maternal immunization. In addition to well-known diseases, new diseases are emerging which pose threats. Several new vaccines are currently under development and increasingly include pregnant women. In this manuscript, targeted at clinicians, vaccinologists, scientists, public health practitioners, and policymakers, we also outline key considerations around maternal immunization introduction and delivery, discuss noninfectious horizons for maternal immunization, and provide a framework for the clinician faced with immunizing a pregnant woman.

Original languageEnglish (US)
Pages (from-to)844-857
Number of pages14
JournalJournal of Perinatology
Volume40
Issue number6
DOIs
StatePublished - Jun 1 2020

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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