TY - GEN
T1 - Closed-Loop Bladder Neuromodulation Therapy in Spinal Cord Injury Rat Model
AU - Raczkowska, Marlena N.
AU - Peh, Wendy Y.X.
AU - Teh, Yuni
AU - Alam, Monzurul
AU - Yen, Shih Cheng
AU - Thakor, Nitish V.
N1 - Funding Information:
This work was funded by the National Research Foundation in Singapore (NRF-CRP10-2012-01) and the GSK Bioelectronics Innovation Challenge (code 100042784). 1Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore (NUS), Singapore 2 School of Medicine, Johns Hopkins University, Baltimore, USA † These authors share senior authorship.
Publisher Copyright:
© 2019 IEEE.
PY - 2019/5/16
Y1 - 2019/5/16
N2 - Poor bladder management is a common and potentially life-threatening dysfunction among spinal cord injury (SCI) patients. In this condition, sensation from the bladder and voluntary control of micturition are lost, which might result in high post-void residual urine volume in the bladder, leading to renal impairment. Micturition can be driven using the sacral anterior root stimulator (SARS). However, commercially available SARS devices are not equipped with a closed-loop regulator for adaptive and automated control of bladder contractions. In our previous study, we developed a closed-loop control strategy for bladder emptying. In this paper we demonstrate the closed-loop neuromodulation feasibility in a SCI rat. The closed-loop strategy in this model achieved 71% voiding efficiency, higher than 40% efficiency obtained using open-loop stimulation. Our results provide a basis for developing an implantable closed-loop neural bladder prosthesis for SCI patients in the future.
AB - Poor bladder management is a common and potentially life-threatening dysfunction among spinal cord injury (SCI) patients. In this condition, sensation from the bladder and voluntary control of micturition are lost, which might result in high post-void residual urine volume in the bladder, leading to renal impairment. Micturition can be driven using the sacral anterior root stimulator (SARS). However, commercially available SARS devices are not equipped with a closed-loop regulator for adaptive and automated control of bladder contractions. In our previous study, we developed a closed-loop control strategy for bladder emptying. In this paper we demonstrate the closed-loop neuromodulation feasibility in a SCI rat. The closed-loop strategy in this model achieved 71% voiding efficiency, higher than 40% efficiency obtained using open-loop stimulation. Our results provide a basis for developing an implantable closed-loop neural bladder prosthesis for SCI patients in the future.
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U2 - 10.1109/NER.2019.8717001
DO - 10.1109/NER.2019.8717001
M3 - Conference contribution
AN - SCOPUS:85066729698
T3 - International IEEE/EMBS Conference on Neural Engineering, NER
SP - 147
EP - 150
BT - 9th International IEEE EMBS Conference on Neural Engineering, NER 2019
PB - IEEE Computer Society
T2 - 9th International IEEE EMBS Conference on Neural Engineering, NER 2019
Y2 - 20 March 2019 through 23 March 2019
ER -