Close correlation of acetaminophen clearance with that of conjugated benzodiazepines but not oxidized benzodiazepines

D. J. Greenblatt, D. R. Abernethy, M. Divoll, R. I. Shader

Research output: Contribution to journalArticle

Abstract

The clearance of the antipyretic-analgesic drug acetaminophen, biotransformed in humans by glucuronide and sulfate conjugation, was evaluated in 32 healthy young and elderly volunteers. Subjects received a single 650-mg dose of acetaminophen, and multiple plasma concentrations measured over the next 12 h. Random subgroups of subjects also participated in studies of the oxidized benzodiazepines diazepam, desmethyldiazepam and alprazolam, and of the conjugated benzodiazepines lorazepam, oxazepam and temazepam. Acetaminophen clearance was not related to that of the oxidized benzodiazepines, but was highly correlated with clearance of lorazepam (r=0.70, n=11, p<0.02), oxazepam (r=0.76, n=14, p<0.005) and temazepam (r=0.63, n=16, p<0.01). Thus acetaminophen may serve as a probe or marker compound to evaluate drug conjugating capacity in humans.

Original languageEnglish (US)
Pages (from-to)113-115
Number of pages3
JournalEuropean journal of clinical pharmacology
Volume25
Issue number1
DOIs
StatePublished - Jan 1983

Keywords

  • acetaminophen clearance
  • benzodiazepines
  • biotransformation
  • conjugation
  • drug conjugating capacity

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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