Clopidogrel resistance?

Paul A. Gurbel, Udaya S. Tantry

Research output: Contribution to journalReview article

Abstract

Clopidogrel is an effective inhibitor of platelet activation and aggregation due to its selective and irreversible blockade of the P2Y12 receptor. Combination antiplatelet therapy with clopidogrel and aspirin is an important strategy for patients with acute coronary syndromes and those undergoing percutaneous interventions. Despite significant benefits demonstrated with combination antiplatelet treatment in large clinical trials, the occurrence of adverse ischemic events, including stent thrombosis, remains a serious clinical problem. Recent studies have demonstrated distinct response variability and nonresponsiveness to clopidogrel therapy based on ex vivo platelet function measurements. Small scale investigations have suggested that nonresponsiveness may be associated with a heightened risk for adverse clinical events. The above findings have stimulated a close examination of clopidogrel metabolism.

Original languageEnglish (US)
Pages (from-to)311-321
Number of pages11
JournalThrombosis research
Volume120
Issue number3
DOIs
StatePublished - Jun 13 2007

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Keywords

  • Clopidogrel
  • P2Y receptor
  • Platelet aggregation
  • Resistance
  • Responsiveness

ASJC Scopus subject areas

  • Hematology

Cite this

Gurbel, P. A., & Tantry, U. S. (2007). Clopidogrel resistance? Thrombosis research, 120(3), 311-321. https://doi.org/10.1016/j.thromres.2006.08.012