TY - JOUR
T1 - Cloning and identification of the human LPAAT-zeta gene, a novel member of the lysophosphatidic acid acyltransferase family
AU - Li, Dan
AU - Yu, Long
AU - Wu, Hai
AU - Shan, Yuxi
AU - Guo, Jinhu
AU - Dang, Yongjun
AU - Wei, Youheng
AU - Zhao, Shouyuan
PY - 2003
Y1 - 2003
N2 - Lysophosphatidic acid (LPA) is a naturally occurring component of phospholipid and plays a critical role in the regulation of many physiological and pathophysiological processes including cell growth, survival, and pro-angiogenesis. LPA is converted to phosphatidic acid by the action of lysophosphatidic acid acyltransferase (LPAAT). Five members of the LPAAT gene family have been detected in humans to date. Here, we report the identification of a novel LPAAT member, which is designated as LPAAT-ζ. LPAAT-ζ was predicted to encode a protein consisting of 456 amino acid residues with a signal peptide sequence and the acyltransferase domain. Northern blot analysis showed that LPAAT-ζ was ubiquitously expressed in all 16 human tissues examined, with levels in the skeletal muscle, heart, and testis being relatively high and in the lung being relatively low. The human LPAAT-ζ gene consisted of 13 exons and is positioned at chromosome 8p11.21.
AB - Lysophosphatidic acid (LPA) is a naturally occurring component of phospholipid and plays a critical role in the regulation of many physiological and pathophysiological processes including cell growth, survival, and pro-angiogenesis. LPA is converted to phosphatidic acid by the action of lysophosphatidic acid acyltransferase (LPAAT). Five members of the LPAAT gene family have been detected in humans to date. Here, we report the identification of a novel LPAAT member, which is designated as LPAAT-ζ. LPAAT-ζ was predicted to encode a protein consisting of 456 amino acid residues with a signal peptide sequence and the acyltransferase domain. Northern blot analysis showed that LPAAT-ζ was ubiquitously expressed in all 16 human tissues examined, with levels in the skeletal muscle, heart, and testis being relatively high and in the lung being relatively low. The human LPAAT-ζ gene consisted of 13 exons and is positioned at chromosome 8p11.21.
KW - Lysophosphatidic acid acyltransferase
KW - Tissue expression pattern
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U2 - 10.1007/s10038-003-0045-z
DO - 10.1007/s10038-003-0045-z
M3 - Article
C2 - 12938015
AN - SCOPUS:0141644278
SN - 1434-5161
VL - 48
SP - 438
EP - 442
JO - Journal of Human Genetics
JF - Journal of Human Genetics
IS - 8
ER -