Cloning and identification of the human LPAAT-zeta gene, a novel member of the lysophosphatidic acid acyltransferase family

Dan Li, Long Yu, Hai Wu, Yuxi Shan, Jinhu Guo, Yongjun Dang, Youheng Wei, Shouyuan Zhao

Research output: Contribution to journalArticle

Abstract

Lysophosphatidic acid (LPA) is a naturally occurring component of phospholipid and plays a critical role in the regulation of many physiological and pathophysiological processes including cell growth, survival, and pro-angiogenesis. LPA is converted to phosphatidic acid by the action of lysophosphatidic acid acyltransferase (LPAAT). Five members of the LPAAT gene family have been detected in humans to date. Here, we report the identification of a novel LPAAT member, which is designated as LPAAT-ζ. LPAAT-ζ was predicted to encode a protein consisting of 456 amino acid residues with a signal peptide sequence and the acyltransferase domain. Northern blot analysis showed that LPAAT-ζ was ubiquitously expressed in all 16 human tissues examined, with levels in the skeletal muscle, heart, and testis being relatively high and in the lung being relatively low. The human LPAAT-ζ gene consisted of 13 exons and is positioned at chromosome 8p11.21.

Original languageEnglish (US)
Pages (from-to)438-442
Number of pages5
JournalJournal of Human Genetics
Volume48
Issue number8
DOIs
StatePublished - 2003
Externally publishedYes

Fingerprint

Forensic Anthropology
Organism Cloning
Genes
Physiological Phenomena
Acyltransferases
Phosphatidic Acids
Protein Sorting Signals
2-acylglycerophosphate acyltransferase
Northern Blotting
Testis
Exons
Phospholipids
Cell Survival
Skeletal Muscle
Chromosomes
Amino Acids
Lung
Growth

Keywords

  • Lysophosphatidic acid acyltransferase
  • Tissue expression pattern

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Cloning and identification of the human LPAAT-zeta gene, a novel member of the lysophosphatidic acid acyltransferase family. / Li, Dan; Yu, Long; Wu, Hai; Shan, Yuxi; Guo, Jinhu; Dang, Yongjun; Wei, Youheng; Zhao, Shouyuan.

In: Journal of Human Genetics, Vol. 48, No. 8, 2003, p. 438-442.

Research output: Contribution to journalArticle

Li, Dan ; Yu, Long ; Wu, Hai ; Shan, Yuxi ; Guo, Jinhu ; Dang, Yongjun ; Wei, Youheng ; Zhao, Shouyuan. / Cloning and identification of the human LPAAT-zeta gene, a novel member of the lysophosphatidic acid acyltransferase family. In: Journal of Human Genetics. 2003 ; Vol. 48, No. 8. pp. 438-442.
@article{88b3f0ea40384ade961e72b31748a3aa,
title = "Cloning and identification of the human LPAAT-zeta gene, a novel member of the lysophosphatidic acid acyltransferase family",
abstract = "Lysophosphatidic acid (LPA) is a naturally occurring component of phospholipid and plays a critical role in the regulation of many physiological and pathophysiological processes including cell growth, survival, and pro-angiogenesis. LPA is converted to phosphatidic acid by the action of lysophosphatidic acid acyltransferase (LPAAT). Five members of the LPAAT gene family have been detected in humans to date. Here, we report the identification of a novel LPAAT member, which is designated as LPAAT-ζ. LPAAT-ζ was predicted to encode a protein consisting of 456 amino acid residues with a signal peptide sequence and the acyltransferase domain. Northern blot analysis showed that LPAAT-ζ was ubiquitously expressed in all 16 human tissues examined, with levels in the skeletal muscle, heart, and testis being relatively high and in the lung being relatively low. The human LPAAT-ζ gene consisted of 13 exons and is positioned at chromosome 8p11.21.",
keywords = "Lysophosphatidic acid acyltransferase, Tissue expression pattern",
author = "Dan Li and Long Yu and Hai Wu and Yuxi Shan and Jinhu Guo and Yongjun Dang and Youheng Wei and Shouyuan Zhao",
year = "2003",
doi = "10.1007/s10038-003-0045-z",
language = "English (US)",
volume = "48",
pages = "438--442",
journal = "Journal of Human Genetics",
issn = "1434-5161",
publisher = "Nature Publishing Group",
number = "8",

}

TY - JOUR

T1 - Cloning and identification of the human LPAAT-zeta gene, a novel member of the lysophosphatidic acid acyltransferase family

AU - Li, Dan

AU - Yu, Long

AU - Wu, Hai

AU - Shan, Yuxi

AU - Guo, Jinhu

AU - Dang, Yongjun

AU - Wei, Youheng

AU - Zhao, Shouyuan

PY - 2003

Y1 - 2003

N2 - Lysophosphatidic acid (LPA) is a naturally occurring component of phospholipid and plays a critical role in the regulation of many physiological and pathophysiological processes including cell growth, survival, and pro-angiogenesis. LPA is converted to phosphatidic acid by the action of lysophosphatidic acid acyltransferase (LPAAT). Five members of the LPAAT gene family have been detected in humans to date. Here, we report the identification of a novel LPAAT member, which is designated as LPAAT-ζ. LPAAT-ζ was predicted to encode a protein consisting of 456 amino acid residues with a signal peptide sequence and the acyltransferase domain. Northern blot analysis showed that LPAAT-ζ was ubiquitously expressed in all 16 human tissues examined, with levels in the skeletal muscle, heart, and testis being relatively high and in the lung being relatively low. The human LPAAT-ζ gene consisted of 13 exons and is positioned at chromosome 8p11.21.

AB - Lysophosphatidic acid (LPA) is a naturally occurring component of phospholipid and plays a critical role in the regulation of many physiological and pathophysiological processes including cell growth, survival, and pro-angiogenesis. LPA is converted to phosphatidic acid by the action of lysophosphatidic acid acyltransferase (LPAAT). Five members of the LPAAT gene family have been detected in humans to date. Here, we report the identification of a novel LPAAT member, which is designated as LPAAT-ζ. LPAAT-ζ was predicted to encode a protein consisting of 456 amino acid residues with a signal peptide sequence and the acyltransferase domain. Northern blot analysis showed that LPAAT-ζ was ubiquitously expressed in all 16 human tissues examined, with levels in the skeletal muscle, heart, and testis being relatively high and in the lung being relatively low. The human LPAAT-ζ gene consisted of 13 exons and is positioned at chromosome 8p11.21.

KW - Lysophosphatidic acid acyltransferase

KW - Tissue expression pattern

UR - http://www.scopus.com/inward/record.url?scp=0141644278&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141644278&partnerID=8YFLogxK

U2 - 10.1007/s10038-003-0045-z

DO - 10.1007/s10038-003-0045-z

M3 - Article

C2 - 12938015

AN - SCOPUS:0141644278

VL - 48

SP - 438

EP - 442

JO - Journal of Human Genetics

JF - Journal of Human Genetics

SN - 1434-5161

IS - 8

ER -