Cloning and expression of two brain-specific inwardly rectifying potassium channels

David S. Bredt, Tian Li Wang, Noam A. Cohen, William B. Guggino, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

Abstract

We have cloned two inwardly rectifying K+ channels that occur selectively in neurons in the brain and are designated BIRK (brain inwardly rectifying K+) channels. BIRK1 mRNA is extremely abundant and is enriched in specific brainstem nuclei, BIRK1 displays a consensus phosphate-binding loop, and expression in Xenopus oocytes has shown that its conductance is inhibited by ATP and adenosine 5'-[γ-thio]triphosphate. BIRK2 is far less abundant and is selectively localized in telencephalic neurons. BIRK2 has a consensus sequence for cAMP-dependent phosphorylation.

Original languageEnglish (US)
Pages (from-to)6753-6757
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume92
Issue number15
DOIs
StatePublished - Jul 18 1995

ASJC Scopus subject areas

  • General

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