Cloning and expression of two brain-specific inwardly rectifying potassium channels

David S. Bredt; Tian Li Wang; Noam A. Cohen; William B. Guggino; Solomon H. Snyder

doi:10.1073/pnas.92.15.6753

Cloning and expression of two brain-specific inwardly rectifying potassium channels

David S. Bredt, Tian Li Wang, Noam A. Cohen, William B. Guggino, Solomon H. Snyder

School of Medicine

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Abstract

We have cloned two inwardly rectifying K⁺ channels that occur selectively in neurons in the brain and are designated BIRK (brain inwardly rectifying K⁺) channels. BIRK1 mRNA is extremely abundant and is enriched in specific brainstem nuclei, BIRK1 displays a consensus phosphate-binding loop, and expression in Xenopus oocytes has shown that its conductance is inhibited by ATP and adenosine 5'-[γ-thio]triphosphate. BIRK2 is far less abundant and is selectively localized in telencephalic neurons. BIRK2 has a consensus sequence for cAMP-dependent phosphorylation.

Original language	English (US)
Pages (from-to)	6753-6757
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	92
Issue number	15
DOIs	https://doi.org/10.1073/pnas.92.15.6753
State	Published - Jul 18 1995

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abstract = "We have cloned two inwardly rectifying K+ channels that occur selectively in neurons in the brain and are designated BIRK (brain inwardly rectifying K+) channels. BIRK1 mRNA is extremely abundant and is enriched in specific brainstem nuclei, BIRK1 displays a consensus phosphate-binding loop, and expression in Xenopus oocytes has shown that its conductance is inhibited by ATP and adenosine 5'-[γ-thio]triphosphate. BIRK2 is far less abundant and is selectively localized in telencephalic neurons. BIRK2 has a consensus sequence for cAMP-dependent phosphorylation.",

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AU - Wang, Tian Li

AU - Cohen, Noam A.

AU - Guggino, William B.

AU - Snyder, Solomon H.

PY - 1995/7/18

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AB - We have cloned two inwardly rectifying K+ channels that occur selectively in neurons in the brain and are designated BIRK (brain inwardly rectifying K+) channels. BIRK1 mRNA is extremely abundant and is enriched in specific brainstem nuclei, BIRK1 displays a consensus phosphate-binding loop, and expression in Xenopus oocytes has shown that its conductance is inhibited by ATP and adenosine 5'-[γ-thio]triphosphate. BIRK2 is far less abundant and is selectively localized in telencephalic neurons. BIRK2 has a consensus sequence for cAMP-dependent phosphorylation.

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Cloning and expression of two brain-specific inwardly rectifying potassium channels

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