Cloning and expression of an adenylyl cyclase localized to the corpus striatum

Charles E. Glatt, Solomon H. Snyder

Research output: Contribution to journalArticle

Abstract

THE neurotransmitter dopamine acts through various receptor subtypes that are largely associated with enhancement or inhibition of adenylyl cyclases 1,2. These dopamine-sensitive adenylyl cyclases are highly concentrated in the corpus striatum and associated limbic structures of the brain, where their levels exceed by orders of magnitude3,4 those in other areas of the brain. Here we use in situ hybridization to show that messenger RNA for three of these adenylyl cyclases5-7 is not found in the corpus striatum. We have isolated and expressed a complementary DNA encoding new adenylyl cyclase whose selective concentration in the corpus striatum indicates that it may be responsible for the synaptic actions of dopamine.

Original languageEnglish (US)
Pages (from-to)536-538
Number of pages3
JournalNature
Volume361
Issue number6412
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • General

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