Clonidine in Morphine Withdrawal: Differential Effects on Signs and Symptoms

Donald R. Jasinski, Rolley E. Johnson, Theresa R. Kocher

Research output: Contribution to journalArticlepeer-review

148 Scopus citations


Reports of an antiwithdrawal effect for clonidine hydrochloride in acute opioid withdrawal are inconsonant with experimental findings that other nonopioids are ineffective. In the present investigation the antiwithdrawal effects of clonidine, morphine sulfate, and placebo were compared in volunteer addicts whose dependence was maintained by 15 mg of morphine sulfate given subcutaneously four times daily. Clonidine was effective but had a differential effect on the signs and symptoms of morphine abstinence. Compared with morphine, clonidine was more effective in suppressing autonomic signs of abstinence but less effective in reducing subject-reported symptoms and discomfort. It is concluded that the perception of the clinical usefulness of clonidine depends on whether objective measures or subjects' reports are treated.

Original languageEnglish (US)
Pages (from-to)1063-1066
Number of pages4
JournalArchives of General Psychiatry
Issue number11
StatePublished - 1985

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health


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