Cloned measles virus-specific T lymphocytes from a twin with multiple sclerosis.

J. R. Richert, H. F. McFarland, D. E. McFarlin, W. J. Bellini, P. Lake

Research output: Contribution to journalArticle

Abstract

A measles virus-specific T lymphocyte clone derived from a measles-responder twin with multiple sclerosis has been produced. The cloned cells proliferate in response to measles virus but not mumps, vaccinia, or canine distemper viruses. The clone recognizes an antigen that is distributed in both the membrane and cytoplasmic fractions of cells infected with measles virus. Antigen is presented to the clone equally well by irradiated mononuclear cells obtained from the autologous subject and from her healthy, measles-nonresponder, HLA-identical twin. Studies with a panel of HLA-typed irradiated mononuclear cells indicate that antigen is presented to the clone in the context of a gene product linked to, but not identical with, HLA-DRw2. The clone produces interleukin 2 and has surface determinants recognized by OKT-3, OKT-4, and anti-HLA-DR monoclonal antibodies, but not by OKT-8. It thus appears to belong to the helper/inducer subpopulation of T lymphocytes.

Original languageEnglish (US)
Pages (from-to)555-559
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume80
Issue number2
StatePublished - Jan 1983
Externally publishedYes

ASJC Scopus subject areas

  • General
  • Genetics

Fingerprint Dive into the research topics of 'Cloned measles virus-specific T lymphocytes from a twin with multiple sclerosis.'. Together they form a unique fingerprint.

  • Cite this