Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

David S. Bredt, Paul M. Hwang, Charles E. Glatt, Charles Lowenstein, Randall R. Reed, Solomon H. Snyder

Research output: Contribution to journalArticle

Abstract

Nitric oxide is a messenger molecule, mediating the effect of endothelium-derived relaxing factor in blood vessels and the cytotoxic actions of macrophages, and playing a part in neuronal communication in the brain. Cloning of a complementary DNA for brain nitric oxide synthase reveals recognition sites for NADPH, FAD, flavin mononucleotide and calmodulin as well as phosphorylation sites, indicating that the synthase is regulated by many different factors. The only known mammalian enzyme with close homology is cytochrome P-450 reductase.

Original languageEnglish (US)
Pages (from-to)714-718
Number of pages5
JournalNature
Volume351
Issue number6329
DOIs
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • General

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