Clonal origin of inherited medullary thyroid carcinoma and pheochromocytoma

Stephen B. Baylin, Donald S. Gann, Susan H. Hsu

Research output: Contribution to journalArticlepeer-review

Abstract

A black female with inherited medullary thyroid carcinoma and pheochromocytoma was a mosaic for glucose-6-phosphate dehydrogenase types A and B in normal tissues (blood, thyroid, and adrenal gland); both the medullary carcinoma and pheochromocytoma tissue showed a B pattern only. This finding suggests a single clone origin for each of the tumors. Other inherited tumors similarly studied in man have appeared to be multiclonal in origin.

Original languageEnglish (US)
Pages (from-to)321-323
Number of pages3
JournalScience
Volume193
Issue number4250
DOIs
StatePublished - Jan 1 1976
Externally publishedYes

ASJC Scopus subject areas

  • General

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